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                                  SCHEDULE 14A
                                 (RULE 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
           PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES
                    EXCHANGE ACT OF 1934 (AMENDMENT NO. ____)


Filed by the Registrant                                          [X]

Filed by a Party other than the Registrant                       [ ]




Check the appropriate box:

[ ]  Preliminary Proxy Statement

[X]  Definitive Proxy Statement

[ ]  Definitive Additional Materials

[ ]  Soliciting Material Under Rule 14a-12

[ ]  Confidential, for Use of the Commission Only (as permitted by Rule
     14a-6(e)(2))


                              MKS INSTRUMENTS, INC.
                (Name of Registrant as Specified in Its Charter)

     (Name of Person(s) Filing Proxy Statement if Other Than the Registrant)


Payment of Filing Fee (check the appropriate box):

[X]  No fee required.

[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

1.   Title of each class of securities to which transaction applies:____________

2.   Aggregate number of securities to which transaction applies:_______________

3.   Per unit price or other underlying value of transaction computed pursuant
     to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is
     calculated and state how it was determined):_______________________________

4.   Proposed maximum aggregate value of transaction:___________________________

5.   Total fee paid:____________________________________________________________

[ ]  Fee paid previously with preliminary materials:____________________________

[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the


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     previous filing by registration statement number, or the form or schedule
     and the date of its filing.

1.   Amount previously paid:____________________________________________________

2.   Form, Schedule or Registration Statement No.:______________________________

3.   Filing Party:______________________________________________________________

4.   Date Filed:________________________________________________________________



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                              MKS INSTRUMENTS, INC.
                                SIX SHATTUCK ROAD
                          ANDOVER, MASSACHUSETTS 01810



                                                                  April 10, 2001

Dear Stockholder:

     You are cordially invited to attend the Annual Meeting of Stockholders of
MKS Instruments, Inc. (the "Company") to be held on Wednesday, May 16, 2001, at
10:00 a.m. at the Andover Country Club, 60 Canterbury Street, Andover,
Massachusetts 01810.

     At the Annual Meeting you will be asked (i) to elect two (2) members of the
Board of Directors of the Company; (ii) to approve an amendment to the Company's
Restated Articles of Organization increasing the number of authorized shares of
Common Stock from 50,000,000 to 75,000,000; (iii) to ratify the appointment of
the Company's independent accountants, PricewaterhouseCoopers LLP; and (iv) to
transact such other business as may properly come before the meeting or any
adjournment thereof. Details of the matters to be considered at the Annual
Meeting are contained in the Proxy Statement, which we urge you to review
carefully.

     Whether or not you plan to attend the Annual Meeting, please complete,
date, sign and return your Proxy promptly in the enclosed envelope, which
requires no postage if mailed in the United States. If you attend the Annual
Meeting, you may vote in person if you wish, even if you have previously
returned your Proxy.

     On behalf of the Board of Directors, I would like to express our
appreciation for your continued interest in the affairs of the Company.


                                             Sincerely,


                                             /s/ John R. Bertucci
                                             -----------------------------------
                                             John R. Bertucci
                                             Chairman

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                              MKS INSTRUMENTS, INC.
                                SIX SHATTUCK ROAD
                          ANDOVER, MASSACHUSETTS 01810

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To the Stockholders:

     NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of MKS
INSTRUMENTS, INC. (the "Company"), a Massachusetts corporation, will be held on
Wednesday, May 16, 2001 at 10:00 a.m. at the Andover Country Club, 60 Canterbury
Street, Andover, Massachusetts 01810, for the following purposes:

     1.   To elect two (2) members of the Board of Directors for a term of three
          (3) years;

     2.   To approve an amendment to the Company's Restated Articles of
          Organization increasing the number of authorized shares of Common
          Stock from 50,000,000 to 75,000,000;

     3.   To consider and act upon a proposal to ratify the appointment by the
          Board of Directors, of PricewaterhouseCoopers LLP as independent
          accountants for the Company for the fiscal year ending December 31,
          2001; and

     4.   To consider and act upon any matters incidental to the foregoing and
          any other matters that may properly come before the meeting or any
          adjournment or adjournments thereof.

     The Board of Directors has no knowledge of any other business to be
transacted at the Annual Meeting.

     The Board of Directors has fixed the close of business on March 30, 2001 as
the record date for the determination of stockholders entitled to notice of and
to vote at the Annual Meeting and any adjournment or adjournments thereof. The
stock transfer books of the Company will remain open for the purchase and sale
of the Company's Common Stock.

     A copy of the Company's Annual Report to Stockholders for the year ended
December 31, 2000, which contains consolidated financial statements and other
information of interest to stockholders, accompanies this Notice and the
enclosed Proxy Statement.

     If you would like to attend the Annual Meeting and your shares are held by
a broker, bank or other nominee, you must bring to the Annual Meeting a letter
from the nominee confirming your beneficial ownership of such shares. You must
also bring a form of personal identification. In order to vote your shares at
the Annual Meeting, you must obtain from the nominee a proxy issued in your
name.

                                        By Order of the Board of Directors


                                        /s/ Richard S. Chute
                                        ----------------------------------------
                                        Richard S. Chute
                                        Clerk

Andover, Massachusetts
April 10, 2001

                                    IMPORTANT

WHETHER OR NOT YOU EXPECT TO ATTEND IN PERSON, PLEASE PROMPTLY SIGN, DATE, AND
RETURN THE ENCLOSED PROXY. PROMPTLY SIGNING, DATING, AND RETURNING THE PROXY
WILL SAVE THE COMPANY THE EXPENSE AND EXTRA WORK OF ADDITIONAL SOLICITATION. AN
ADDRESSED ENVELOPE FOR WHICH NO POSTAGE IS REQUIRED IF MAILED IN THE UNITED
STATES IS ENCLOSED FOR THAT PURPOSE. SENDING IN YOUR PROXY WILL NOT PREVENT YOU
FROM VOTING YOUR STOCK AT THE ANNUAL MEETING IF YOU DESIRE TO DO SO, AS YOUR
PROXY IS REVOCABLE AT YOUR OPTION.


                                       1
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                              MKS INSTRUMENTS, INC.
                                SIX SHATTUCK ROAD
                          ANDOVER, MASSACHUSETTS 01810

                                 PROXY STATEMENT

     This Proxy Statement is furnished in connection with the solicitation of
proxies by the Board of Directors of MKS Instruments, Inc. (the "Company" or
"MKS"), a Massachusetts corporation, for use at the Annual Meeting of
Stockholders to be held on May 16, 2001, at 10:00 a.m. at the Andover Country
Club, 60 Canterbury Street, Andover, Massachusetts 01810, and at any adjournment
or postponement thereof (the "Annual Meeting").

     All proxies will be voted in accordance with the stockholders'
instructions. If no choice is specified, the shares will be voted in favor of
the matters set forth in the accompanying Notice of Annual Meeting of
Stockholders. Any proxy may be revoked by a stockholder at any time before its
exercise by delivery of written revocation to the Clerk of the Company.
Attendance at the Annual Meeting will not in itself be deemed to revoke a Proxy
unless the stockholder gives affirmative notice at the Annual Meeting that the
stockholder intends to revoke the proxy and vote in person.

VOTING SECURITIES AND VOTES REQUIRED


     On March 30, 2001, the record date for the determination of stockholders
entitled to notice of and to vote at the Annual Meeting, there were issued and
outstanding and entitled to vote 36,895,936 shares of Common Stock, no par value
per share (the "Common Stock"). Each share entitles the record holder to one
vote on each matter.


     Under the Company's Amended and Restated By-Laws (the "By-Laws"), the
holders of a majority of the shares of Common Stock issued and outstanding and
entitled to vote at the Annual Meeting shall constitute a quorum for the
transaction of business at the Annual Meeting. Shares of Common Stock present in
person or represented by proxy (including shares which abstain or do not vote
with respect to one or more of the matters presented for stockholder approval)
will be counted for purposes of determining whether a quorum exists at the
Annual Meeting.

     The affirmative vote of the holders of a plurality of the shares of Common
Stock voting on the matter is required for the election of Directors. The
affirmative vote of the holders of a majority of the outstanding shares of
Common Stock is required to approve the proposed amendment to the Company's
Restated Articles of Organization. All other matters require the approval of the
holders of a majority of the shares of Common Stock present at the Annual
Meeting or represented by proxy.

     Shares held by stockholders who abstain from voting as to a particular
matter, and shares held in "street name" by brokers or nominees, who indicate on
their proxies that they do not have discretionary authority to vote such shares
as to a particular matter, will not be counted as votes in favor of such matter,
and also will not be counted as shares voting on such matter. Accordingly,
abstentions and "broker non-votes" will have no effect on the voting on a matter
that requires the affirmative vote of a certain percentage of the shares voting
on the matter. However, because shares which abstain and shares represented by
broker non-votes are nonetheless considered outstanding shares, abstentions and
broker non-votes with respect to the proposed amendment to the Company's
Restated Articles of Organization will have the same effect as a vote against
such proposed amendment.

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     THE NOTICE OF ANNUAL MEETING, THIS PROXY STATEMENT AND THE COMPANY'S ANNUAL
REPORT TO STOCKHOLDERS FOR THE YEAR ENDED DECEMBER 31, 2000, ARE BEING MAILED TO
STOCKHOLDERS ON OR ABOUT APRIL 12, 2001. A COPY OF THE COMPANY'S ANNUAL REPORT
ON FORM 10-K FOR THE YEAR ENDED DECEMBER 31, 2000, AS FILED WITH THE SECURITIES
AND EXCHANGE COMMISSION (THE "COMMISSION"), EXCLUDING EXHIBITS, WILL BE
FURNISHED WITHOUT CHARGE TO ANY STOCKHOLDER UPON WRITTEN REQUEST TO CCBN.COM
INVESTOR CONNECT, ATTN: MARK BERGERON, GWS, 148 WARD HILL, HAVERHILL, MA 01835.
EXHIBITS WILL BE PROVIDED UPON WRITTEN REQUEST AND PAYMENT OF AN APPROPRIATE
PROCESSING FEE.


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                    SECURITY OWNERSHIP OF CERTAIN BENEFICIAL
                              OWNERS AND MANAGEMENT

     The following table sets forth certain information with respect to the
beneficial ownership of Common Stock by (i) each stockholder known to the
Company to be the beneficial owner of more than 5% of the outstanding shares of
Common Stock; (ii) each current director of the Company; (iii) the executive
officers named in the Summary Compensation Table below; and (iv) all directors
and executive officers of the Company as a group. Unless otherwise indicated in
the footnotes to the table, (i) all information set forth in the table is as of
January 31, 2001; and (ii) the address for each director and executive officer
of the Company is: c/o MKS Instruments, Inc., Six Shattuck Road, Andover,
Massachusetts 01810.




                                                      Number of Shares               Percentage of Class
Name of Beneficial Owners                             Beneficially Owned (1)         Outstanding

                                                                               
John R. Bertucci........................................  15,245,610  (2)                  41.4%
Peter R. Younger........................................      58,482  (3)                     *
Ronald C. Weigner.......................................     160,957  (4)                     *
William D. Stewart......................................     160,502  (5)                     *
Robert L. Klimm.........................................      18,750  (6)                     *
Joseph A. Maher.........................................     111,704  (7)                     *
Richard S. Chute........................................   1,788,583  (8)                   4.9%
Owen W. Robbins.........................................      25,092  (6)                     *
Robert J. Therrien......................................      25,092                          *
Louis P. Valente........................................      25,092  (6)                     *
Robert R. Anderson......................................      73,515  (9)                     *
Hans-Jochen Kahl........................................      46,913  (10)                    *
Other 5% stockholder
Thomas H. Belknap.......................................   1,668,696  (11)                  4.5%
All directors and executive officers as a group
(18 persons)............................................  17,102,770  (12)                 45.5%



---------------

*    Represents less than 1% of the outstanding Common Stock.

(1)  The Company believes that each stockholder has sole voting and investment
     power with respect to the shares listed, except as otherwise noted. The
     number of shares beneficially owned by each stockholder is determined under
     rules of the Commission, and the information is not necessarily indicative
     of ownership for any other purpose. Under such rules, beneficial ownership
     includes any shares as to which the person has sole or shared voting power
     or investment power and also any shares which the individual has the right
     to acquire within 60 days after January 31, 2001 through the exercise of
     any stock option or other right. The inclusion herein of any shares of
     Common Stock deemed beneficially owned does not constitute an admission by
     such stockholder of beneficial ownership of those shares of Common Stock.
     Shares of Common Stock which an individual or entity has a right to acquire
     within the 60-day period following January 31, 2001 pursuant to the
     exercise of options or warrants are deemed to be outstanding for the
     purpose of computing the percentage ownership of such individual or entity,
     but are not deemed to be outstanding for the purpose of computing the
     percentage ownership of any other person or entity shown in the table.

(2)  Includes 5,840,906 shares held directly by Mr. Bertucci, 5,939,125 shares
     held directly by Mr. Bertucci's family members, and 3,431,837 shares held
     by Bertucci family trusts for which either Mr. or Mrs. Bertucci serves as a
     co-trustee. In addition, includes 33,742 shares subject to options
     exercisable within 60 days of January 31, 2001.

(3)  Includes 1,532 shares held directly by Mr. Younger, 700 shares held by
     certain of the Younger family trusts for which Mr. Younger serves as
     trustee, and 56,250 shares subject to options exercisable within 60 days of
     January 31, 2001.

(4)  Includes 1,357 shares held directly by Mr. Weigner and 159,600 shares
     subject to options exercisable within 60 days of January 31, 2001.

(5)  Includes 1,152 shares held directly by Mr. Stewart and 159,350 shares
     subject to options exercisable within 60 days of January 31, 2001.

                                       4
   8

(6)  Consists of shares subject to options exercisable within 60 days of January
     31, 2001.

(7)  Includes 12,049 shares held directly by Mr. Maher and 99,655 shares subject
     to options exercisable within 60 days of January 31, 2001.

(8)  Includes 1,763,491 shares held by certain of the Bertucci family trusts for
     which Mr. Chute serves as a co-trustee and 25,092 shares subject to options
     held by Mr. Chute exercisable within 60 days of January 31, 2001.

(9)  Includes 32,871 shares held directly by Mr. Anderson, 11,503 shares held in
     trust for the benefit of a child of Mr. Anderson, of which Mr. Anderson is
     the trustee, and 29,141 shares subject to options exercisable within 60
     days of January 31, 2001.

(10) Includes 20,206 shares held directly by Mr. Kahl, 4,084 shares held by Mr.
     Kahl's wife, and 22,623 shares subject to options exercisable within 60
     days of January 31, 2001.

(11) Includes 1,668,346 shares held by certain of the Bertucci family trusts for
     which Mr. Belknap serves as a co-trustee and 350 shares held directly by
     Mr. Belknap.

(12) Includes 807,812 shares subject to options exercisable within 60 days of
     January 31, 2001.

     To the knowledge of the Company, there are no agreements among any of the
foregoing persons or entities with respect to the voting of shares of Common
Stock of the Company.

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                                  PROPOSAL ONE

                              ELECTION OF DIRECTORS

     The By-Laws of the Company provide for a Board of Directors which is
divided into three classes. The term of the Class I Directors expires at the
2003 Annual Meeting. The term of the Class II Directors expires at the 2001
Annual Meeting, and the term of the Class III Directors expires at the 2002
Annual Meeting. Mr. Owen W. Robbins and Mr. Richard S. Chute are currently
proposed for election to serve as Class II Directors.

     Shares represented by all proxies received by the Board of Directors and
not so marked as to withhold authority to vote for an individual director will
be voted (unless one or both nominees are unable or unwilling to serve) for the
election of the nominees named below. The Board of Directors expects that each
of the nominees named below will be available for election, but if either of
them is not a candidate at the time the election occurs, it is intended that
such proxies will be voted for the election of a substitute nominee to be
designated by the Board of Directors.


     THE BOARD OF DIRECTORS RECOMMENDS THE ELECTION OF MR. OWEN W. ROBBINS AND
MR. RICHARD S. CHUTE AS DIRECTORS, EACH TO SERVE A TERM WHICH EXPIRES AT THE
2004 ANNUAL MEETING.


                                    DIRECTORS

     Set forth below are the names and ages of each member of the Board of
Directors (including those who are nominees for election as Class II Directors)
and the positions and offices held by him, his principal occupation and business
experience during the past five years, the names of other publicly held
companies of which he serves as a director and the year of the commencement of
his term as director of MKS. Information with respect to the number of shares of
Common Stock beneficially owned by each director, directly or indirectly, as of
January 31, 2001, appears under the heading "Security Ownership of Certain
Beneficial Owners and Management."




                                                                                       Class to Which
Name                                  Age         Position                             Director Belongs
----                                  ---         --------                             -----------------
                                                                              
John R. Bertucci.....................  60         Director; Chairman and Chief               III
                                                  Executive Officer
*Richard S. Chute....................  62         Director; Clerk                             II
*Owen W. Robbins (2).................  71         Director                                    II
Robert J. Therrien (1)...............  66         Director                                     I
Louis P. Valente (1)(2)..............  70         Director                                     I
Robert R. Anderson(2)................  63         Director                                   III
Hans-Jochen Kahl(1)..................  61         Director                                     I


--------------------------------------------------------------------------------

(1)  Member of Compensation Committee.

(2)  Member of Audit Committee.

*    Nominee for election at this meeting.

     Mr. Bertucci has served as a director of MKS since 1974 and has been
Chairman of the Board of Directors and Chief Executive Officer since November
1995. Mr. Bertucci served as President of MKS from 1974 to May 1999. From 1970
to 1974, he was Vice President and General Manager. Mr. Bertucci has an M.S. in
Industrial Administration and a B.A. in Metallurgical Engineering from
Carnegie-Mellon University. Mr. Bertucci is also a director of Intellisense
Corporation, and was a director of Applied Science and Technology, Inc.
("ASTeX") from September 1994 to January 2001, when ASTeX was acquired by MKS.

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     Mr. Chute has served as a director of MKS since 1974. Mr. Chute has been a
member of the law firm of Hill & Barlow, a Professional Corporation, since 1971.

     Mr. Robbins has served as a director of MKS since February 1996. Mr.
Robbins was Executive Vice President of Teradyne, Inc., a manufacturer of
electronic test systems and backplane connection systems used in the electronics
and telecommunications industries, from March 1992 to May 1997, and its Chief
Financial Officer from February 1980 to May 1997. Mr. Robbins served on the
Board of Directors of Teradyne, Inc. from March 1992 to May 2000, at which time
he retired as a Director, and was its Vice Chairman from January 1996 to May
1997, at which time he retired from Teradyne, Inc.

     Mr. Therrien has served as a director of MKS since February 1996. Mr.
Therrien has been President and Chief Executive Officer of Brooks Automation,
Inc., a manufacturer of semiconductor processing equipment, since 1989.

     Mr. Valente has served as a director of MKS since February 1996. Mr.
Valente has been Chairman and Chief Executive Officer of Palomar Medical
Technologies, Inc., a company which designs, manufactures and markets cosmetic
lasers, since September 1997. He has been a director of Palomar Medical
Technologies, Inc. since February 1997 and was its President and Chief Executive
Officer from May 1997 to September 1997. Mr. Valente is also a director of two
privately held medical software companies.

     Mr. Anderson has served as a director of MKS since January 2001. Mr.
Anderson is a private investor. From October 1998 to October 2000, Mr. Anderson
served as Chief Executive Officer of Yield Dynamics, Inc., a private
semiconductor control software company and presently serves as a director. He
also served as CEO of Silcon Valley Research, Inc., a semiconductor design
automation software company from December 1996 to August 1998. Mr. Anderson
currently serves as a director of Metron Technology N.V., a distributor of parts
and equipment for the semiconductor industry, Trikon Technologies, Inc., a
manufacturer of semiconductor process equipment, and Aehr Test Systems, Inc., a
manufacturer of semiconductor test and burn in equipment. He also serves as a
director to three other private development stage companies, and as a trustee of
Bentley College. Mr. Anderson also served as a director of Applied Science and
Technology, Inc. ("ASTeX") from October 1995 to January 2001, when ASTeX was
acquired by MKS.

     Mr. Kahl has served as a director of MKS since January 2001. From June 1994
through September 1996, Mr. Kahl served as a consultant to Ebara, a Japanese
manufacturer of industrial water pumps and vacuum process equipment for the
semiconductor industry. Mr. Kahl was employed by Leybold AG, formerly
Leybold-Heraeus GmbH, a leading international manufacturer of vacuum pumps and
other vacuum process equipment for the semiconductor industry, from July 1983 to
March 1992, where he served as a managing director and was primarily responsible
for sales, marketing and strategic planning. Since November 1996, he has served
as a director of Solid State Management, a privately held manufacturer of high
precision measurement tools. Mr. Kahl served as a director of Compact Instrument
Technology, LLC, of Woburn, Massachusetts from May 1999 until March 2000, when
Compact was acquired by MKS. Mr. Kahl also served as a director of ASTeX from
October 1995 to January 2001, when ASTeX was acquired by MKS.

DIRECTOR COMPENSATION

     Directors of MKS are reimbursed for expenses incurred in connection with
their attendance at Board of Directors and committee meetings. Directors who are
not employees of MKS are paid an annual fee of $10,000 and $1,000 for each Board
of Directors meeting they attend and $500 for each committee meeting they attend
which is not held on the same day as a Board of Directors meeting. Messrs.
Chute, Robbins, Therrien and Valente, four of MKS's non-employee directors, have
each been granted options, under MKS's 1996 Director Stock Option Plan (under
which no further grants will be made), to purchase 8,592 shares of Common Stock
at a weighted average exercise price of $4.81 per share. Each has also been
granted options to purchase 22,500 shares of Common Stock at a weighted average
exercise price of $22.34 per share under the 1997 Director Stock Option Plan
(the "1997 Director Plan"). Mr. Anderson and Mr. Kahl have each been granted
options to purchase 11,250 shares of Common Stock at an exercise price of
$20.125 per share under the 1997 Director Plan.

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   11

1997 DIRECTOR STOCK OPTION PLAN

     MKS's 1997 Director Plan authorizes the issuance of up to an aggregate of
300,000 shares of Common Stock. The 1997 Director Plan is administered by MKS's
Board of Directors. Options are granted under the 1997 Director Plan only to
directors of MKS who are not employees of MKS. Under the 1997 Director Plan,
non-employee directors receive an option to purchase 11,250 shares of common
stock upon their initial election to the Board of Directors. Each initial option
vests over a three-year period in twelve (12) equal quarterly installments
following the date of grant. On the date of each annual meeting of the
stockholders, options are automatically granted to each eligible director who
has been in office for at least six (6) months prior to the date of the annual
meeting of the stockholders. Each annual option entitles the holder to purchase
6,000 shares of Common Stock. Each annual option will generally become
exercisable on the day prior to the first annual meeting of stockholders
following the date of grant, or if no such meeting is held within thirteen (13)
months after the date of grant, on the thirteen (13) month anniversary of the
date of grant. The exercise price of all options granted under the 1997 Director
Plan is equal to the fair market value of the Common Stock on the date of grant.
Options granted under the 1997 Director Plan terminate upon the earlier of three
(3) months after the optionee ceases to be a director of MKS or ten (10) years
after the grant date. In the event of a change in control of MKS, the vesting of
all options then outstanding would be accelerated in full and any restrictions
on exercising outstanding options would terminate.

     The Company's 1996 Director Stock Option Plan, under which options have
been granted to, and may still be exercised by, four non-employee directors of
MKS, has been terminated. See "Director Compensation."

COMMITTEES OF THE BOARD OF DIRECTORS

     The Compensation Committee for the year 2000 consisted of Messrs. Therrien
and Valente. Mr. Kahl joined the Compensation Committee in February 2001. The
Compensation Committee reviews and evaluates the salaries, supplemental
compensation and benefits of all officers of MKS, reviews general policy matters
relating to compensation and benefits of employees of MKS and makes
recommendations concerning these matters to the Board of Directors. The
Compensation Committee also administers MKS's stock option and stock purchase
plans.

     The Audit Committee for the year 2000 consisted of Messrs. Robbins,
Therrien and Valente. Mr. Therrien resigned from the Audit Committee in February
2001 and Mr. Anderson joined the Audit Committee in February 2001. The Audit
Committee reviews with MKS's independent auditor the scope and timing of its
audit services, the auditor's report on MKS's financial statements following
completion of its audit and MKS's policies and procedures with respect to
internal accounting and financial controls. In addition, the Audit Committee
will make annual recommendations to the Board of Directors for the appointment
of independent auditors for the ensuing year.

     The Board of Directors held eight (8) meetings during 2000. Each director
attended at least 75% of the total number of meetings of the Board of Directors
and all committees of the Board on which he served.

             COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

     The Company's executive compensation program is administered by the
Compensation Committee of the Board of Directors. In January 2000, Mr. Chute
resigned from the Compensation Committee. For the remainder of 2000, the
Compensation Committee was comprised of two non-employee directors, Messrs.
Therrien and Valente (the "Committee"). Mr. Kahl joined the Committee in
February 2001. The Committee is responsible for determining the salaries of,
establishing bonus programs for, and granting stock options to, the Company's
executive officers.

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   12

     The Committee believes that the primary objectives of the Company's
compensation policies are to attract, retain, motivate, and reward a management
team that can effectively implement and execute the Company's strategic business
plan and lead the Company in achieving its long-term growth and earnings goals.
These compensation policies include an overall management compensation program
that: (i) is competitive with management compensation programs at companies of
similar size; (ii) recognizes individual initiative, leadership and achievement;
(iii) provides short-term bonus incentives for management to meet the Company's
net income performance goals; and (iv) provides long-term incentive compensation
in the form of stock options to encourage management to continue to focus on
shareholder return.

     The Committee's goal is to use compensation policies to closely align the
interests of the Company's management with the interests of shareholders so that
the Company's management have incentives to achieve short-term performance goals
while building long-term value for the Company's shareholders. In establishing
base salaries for executive officers, the Committee considers numerous factors
such as the executive's responsibilities, the executive's importance to the
Company, the executive's performance, historical salary levels of the executive,
and the salaries of executives at certain other companies whose business is
similar to that of the Company. The Committee will review its compensation
policies from time to time in order to determine the reasonableness of the
Company's compensation programs and to take into account factors which are
unique to the Company.

     The Company has entered into employment agreements with certain senior
officers of the Company. The Committee believes that the salaries and benefits
provided to these senior officers reflect appropriate base salaries and benefits
as compared to senior officers of other companies of similar size. These
agreements provide for termination for cause as well as termination without
cause and restrict the officers' ability to compete with the Company.


BONUS PLAN


     To further provide incentives for management to continue to improve
operating results, the Board of Directors implemented the Management Incentive
Plan ("Bonus Plan"). The amounts to be distributed pursuant to the Bonus Plan
are determined by the income generated by the Company. The Committee believes
that the Bonus Plan provides significant incentive to the executive officers of
the Company to exceed the Company's income goals.


LONG-TERM INCENTIVE COMPENSATION


     Long-term incentive compensation, in the form of stock options, allows the
executive officers to share in any appreciation in the value of the Company's
Common Stock. The Committee believes that stock option participation aligns
executive officers' interests with those of the stockholders. In addition, the
Committee believes that awarding options to executive officers helps to balance
the short-term focus of annual incentive compensation with a longer term view
and may help to retain key executive officers. Moreover, because options granted
to executive officers generally become exercisable over a four or five year
period and terminate upon or shortly after the termination of the executive's
employment with the Company, stock options serve as a means of retaining these
executives.

     When establishing stock option grant levels, the Committee considers
general corporate performance, the Chief Executive Officer's recommendations,
level of seniority and experience, the dilutive impact of the options, previous
grants of stock options, vesting schedules of outstanding options and the
current stock price.

     It is the policy of the Company to make an initial stock option grant to
all executive officers at the time they commence employment consistent with the
number of options granted to executive officers in the industry at similar
levels of seniority. In addition, the Committee may also make grants throughout
the year. In making such grants, the Committee considers individual
contributions to the Company's financial, operational and strategic objectives.

                                       9
   13

     Senior management also participates in Company-wide employee benefit plans,
including the Company's 401(k) Plan. Benefits under these plans are not
dependent upon individual performance.


COMPENSATION OF CHIEF EXECUTIVE OFFICER


     Mr. Bertucci's compensation was based upon a careful analysis of other
comparable companies' Chief Executive Officers' compensation and Mr. Bertucci's
efforts and success in improving the Company's operating results, establishing
strategic goals and objectives for long-term growth of the Company, and
advancing the Company in obtaining its strategic goals.


SECTION 162(m)


     Section 162(m) of the Internal Revenue Code generally disallows a tax
deduction to public companies for certain compensation in excess of $1.0 million
paid to the company's chief executive officer and the four other most highly
compensated executive officers. Certain compensation, including qualified
performance-based compensation, will not be subject to the deduction limit if
certain requirements are met.

     The Committee reviews the potential effect of Section 162(m) periodically
and generally seeks to structure the long-term incentive compensation granted to
its executive officers through option issuances under the Amended and Restated
1995 Stock Incentive Plan in a manner that is intended to avoid disallowances
under Section 162(m). However, because the Company's Bonus Plan is not operated
in a manner designed to qualify as performance-based compensation under Section
162(m), it is possible that a portion of any bonus payable to Mr. Bertucci and
certain other executives under the Bonus Plan will not be deductible for federal
income tax purposes. The Committee reserves the right to use its judgment to
authorize compensation payments which may be in excess of the Section 162(m)
limit when the Committee believes such payments are appropriate, after taking
into consideration changing business conditions or the officer's performance,
and are in the best interests of the stockholders.



                                   -------------------------------
                                   Compensation Committee for 2000
                                   Louis P. Valente, Chairman
                                   Robert J. Therrien


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION


     In 2000, the Compensation Committee comprised Messrs. Therrien and Valente.
Messrs. Therrien and Valente were not, at any time, officers or employees of MKS
or any subsidiary of MKS, and neither had any relationship with MKS requiring
disclosure under Item 404 of Regulation S-K under the Securities Exchange Act of
1934, as amended (the "Exchange Act"). No executive officer of MKS serves or has
served as a member of the Board of Directors or Compensation Committee (or other
committee serving an equivalent function) of any other entity which has one or
more executive officers serving as a member of MKS's Board of Directors or
Compensation Committee.

                                       10
   14

             REPORT OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS

     The Audit Committee of the Company's Board of Directors is currently
composed of three members and acts under a written charter first adopted and
approved in 2000. A copy of this charter is attached to this proxy statement as
APPENDIX B. The members of the Audit Committee are independent directors, as
defined by its charter and the rules of the Nasdaq Stock Market, and possess the
financial sophistication required by such charter and rules. The Audit Committee
held two meetings during 2000.


     Management is responsible for the Company's internal controls and the
financial reporting process. The Company's independent accountants are
responsible for performing an independent audit of the Company's financial
statements in accordance with generally accepted accounting principles and issue
a report on those financial statements. The Audit Committee is responsible for
monitoring and overseeing these processes. As appropriate, the Audit Committee
reviews and evaluates, and discusses with the Company's management, internal
accounting, financial and auditing personnel and the independent auditors, the
following:

-    the plan for, and the independent auditors' report on, each audit of the
     Company's financial statements;
-    the Company's financial disclosure documents, including all financial
     statements and reports filed with the Securities and Exchange Commission or
     sent to shareholders;
-    changes in the Company's accounting practices, principles, controls or
     methodologies;
-    significant developments or changes in accounting rules applicable to the
     Company; and
-    the adequacy of the Company's internal controls and accounting, financial
     and auditing personnel.

     The Audit Committee reviewed the Company's audited financial statements for
the fiscal year ended December 31, 2000, and discussed these financial
statements with the Company's management. Management represented to the Audit
Committee that the Company's financial statements had been prepared in
accordance with generally accepted accounting principles. The Audit Committee
also reviewed and discussed the audited financial statements and the matters
required by Statement on Auditing Standards 61 Communication with Audit
Committees with the Company's independent auditors. SAS 61 requires the
Company's independent auditors to discuss with the Company's Audit Committee,
among other things, the following:

-    methods to account for significant unusual transactions;
-    the effect of significant accounting policies in controversial or emerging
     areas for which there is a lack of authoritative guidance or consensus;
-    the process used by management in formulating particularly sensitive
     accounting estimates and the basis for the auditors' conclusions regarding
     the reasonableness of those estimates; and
-    disagreements with management over the application of accounting
     principles, the basis for management's accounting estimates and the
     disclosures in the financial statements.

     The Company's independent auditors also provided the Audit Committee with
the written disclosures and the letter required by Independence Standards Board
Standard No. 1 (Independence Discussions with Audit Committees). Independence
Standards Board Standard No. 1 requires auditors annually to disclose in writing
all relationships that in the auditor's professional opinion may reasonably be
thought to bear on independence, confirm their perceived independence and engage
in a discussion of independence. In addition, the Audit Committee discussed with
the independent auditors their independence from the Company.

                                       11
   15

     Based on its discussions with management and the independent auditors, and
its review of the representations and information provided by management and the
independent auditors, the Audit Committee recommended to the Company's Board of
Directors that the audited financial statements be included in the Company's
Annual Report on Form 10-K for the year ended December 31, 2000.

     Management has advised us that for the year ended December 31, 2000, the
Company was billed by its independent auditors, PricewaterhouseCoopers LLP
("PwC") for services in the following categories:

     Audit Fees:

     PwC billed the Company an aggregate of $264,000 in fees for professional
services rendered in connection with the audit of the Company's financial
statements for the most recent fiscal year and the reviews of the financial
statements included in each of the Company's Quarterly Reports on Form 10-Q
during the last fiscal year.

     Financial Information Systems Design and Implementation Fees:

     PwC did not bill the Company for any professional services rendered for the
most recent fiscal year in connection with financial information systems design
or implementation, the operation of the Company's information system or the
management of its local area network.

     All Other Fees(1):

     PwC billed the Company an aggregate of $1,171,000 for all other services
rendered for the most recent fiscal year.

---------

(1)  All Other Fees includes fees for the following routine audit and tax
     services:



                                                                
     Tax advice and tax return assistance......................    $417,000

     Due diligence, accounting and tax advice in support
     of acquisitions and related offering statements...........    $754,000



     We have considered and determined that the provision of the non-audit
services noted in the foregoing table is compatible with maintaining PWC's
independence.

     By the Audit Committee of the Board of Directors of MKS Instruments, Inc.


                                   ----------------------------
                                   Audit Committee for 2000
                                   Owen W. Robbins, Chairman
                                   Robert J. Therrien
                                   Louis P. Valente


                                       12
   16

                               EXECUTIVE OFFICERS



Name                                                        Age    Position
----                                                        ---    --------

                                                             
John R. Bertucci.....................................       60     Chairman and Chief Executive Officer
Peter R. Younger.....................................       56     President and Chief Operating Officer
Ronald C. Weigner....................................       55     Vice President and Chief Financial
                                                                   Officer
William D. Stewart...................................       56     Vice President and General Manager,
                                                                   HPS Products
Robert L. Klimm......................................       50     Vice President and General Manager,
                                                                   Materials Delivery and Analysis Products
Leo Berlinghieri.....................................       47     Vice President, Global Sales and Service
F. Thomas McNabb.....................................       40     Vice President and General Manager,
                                                                   Pressure Measurement and Control
                                                                   Products
Richard S. Post......................................       57     Vice President, Business Development
John E. Ross.........................................       56     Vice President and General Manager,
                                                                   ASTeX Products


--------------------------------------------------------------------------------

     The following is a brief summary of the background of each executive
officer of MKS, other than Mr. Bertucci, whose background is described above:

     Mr. Younger joined MKS in May 1999 as President and Chief Operating
Officer. He was most recently Vice President and General Manager of Eaton's
Semiconductor Equipment Operations. Mr. Younger is currently a Board member of
Semiconductor Equipment and Materials International (SEMI), a global association
of approximately 2,200 member companies in the semiconductor equipment and
materials industry, and was the organization's chairman from 1997 to 1998. In
addition, he served on the Board of Directors for the North Shore Chamber of
Commerce from 1993 to 1997. Mr. Younger holds an A.B. in Physics from Cornell
University, and an M.A. and Ph.D. in Physics from Boston University.

     Mr. Weigner has served as Vice President and Chief Financial Officer of MKS
since November 1995. From September 1993 until November 1995, he was Vice
President and Corporate Controller and from 1980 to 1993 he was Corporate
Controller. Mr. Weigner is a certified public accountant and has a B.S. in
Business Administration from Boston University.

     Mr. Stewart has served as Vice President and General Manager, HPS Products
group since November 1997. From October 1986 to November 1997, he was President
of HPS Products group, which MKS acquired in 1986. Mr. Stewart co-founded HPS in
1976. Mr Stewart has an M.B.A. from Northwestern University and a B.S. in
Business Administration from the University of Colorado. Mr. Stewart also serves
on the Board of Directors of the Janus Fund.

     Mr. Klimm has served as Vice President and General Manager, Materials
Delivery and Analysis Products group of MKS since December 1999. Mr. Klimm was
Vice President and General Manager of the Factory Automation Division of PRI
Automation from 1997 to 1999. From 1990 to 1997 he held various positions at
Eaton's Semiconductor Equipment Operations, culminating as General Manager of
the Implant Systems Division. Mr. Klimm has an M.B.A. from the Sloan School at
MIT, an M.A. in Electrical Engineering from Northeastern University and a B.S.
in Electrical Engineering from Lehigh University.

     Mr. Berlinghieri has served as Vice President, Global Sales and Service of
MKS since November 1995. From 1980 to November 1995, he served in various
management positions of MKS, including Manufacturing Manager, Production and
Inventory Control Manager, and Director of Customer Support Operations. Mr.
Berlinghieri is also Treasurer of the TQM-BASE Council, Inc., a non-profit
quality management consortium comprised of Boston-area semiconductor capital
equipment manufacturers.

                                       13
   17

     Mr. McNabb has served as Vice President and General Manager, Pressure
Measurement and Control Products group of MKS since October 2000. From September
1997 to October 2000, he managed several business units at PRI Automation,
culminating as Vice President of Lithography Automation and then Vice President
of Factory Systems Engineering. From 1983 to 1997, Mr. McNabb held a variety of
management positions with Texas Instruments, including Marketing, Operations,
Engineering Applications, Program Management, Business Development, and Business
Unit Management. Mr. McNabb has a B.S. in Civil Engineering from the University
of Vermont.

     Mr. Post has served as Vice President, Business Development of MKS since
January 2001. Mr. Post founded ASTeX in 1987 and served as its Chief Executive
Officer and Chairman of the Board until January 2001. From 1981 to 1987, Mr.
Post served as a Senior Research Scientist at the Massachusetts Institute of
Technology. At MIT, Mr. Post served in the position of head of the Mirror
Confinement Division of the Plasma Fusion Center. Mr. Post earned his Ph.D. in
plasma physics from Columbia University and his B.S. from the University of
California at Berkeley. He has also completed the owner/president management
program at Harvard Business School.

     Mr. Ross has been Vice President and General Manager, ASTeX Products group
of MKS since January 2001. Mr. Ross was the President and Chief Operating
Officer of ASTeX from August 2000 until it was acquired by MKS, and was ASTeX's
Senior Vice President, Global Customer Operations from June 2000 until August
2000, its Vice President, Business Development, from January 2000 until June
2000 and served as a Consultant to ASTeX from September 1999 until January 2000.
From June 1998 to May 1999, Mr. Ross was the Senior Vice President of Operations
at Topaz Technologies, a company that designs and manufactures professional,
wide format ink jet printing systems. From June 1993 to June 1998, Mr. Ross was
the General Manager and Vice President of Operations at Applied Magnetics
Corporation, a manufacturer of read/write recording heads for computer disk
drives. Mr. Ross is also a director of Life Quality Products, Inc., a
privately-held company. Mr. Ross holds a B.S. in Chemistry from Hull University
in Hull, England.

     Executive officers of MKS are elected by the Board of Directors on an
annual basis and serve until their successors are duly elected and qualified.
There are no family relationships among any of the executive officers or
directors of MKS.

                                       14
   18


EXECUTIVE COMPENSATION


     The following table sets forth information with respect to the compensation
of MKS's Chief Executive Officer, each of the four other most highly compensated
executive officers (the "Named Executive Officers") and Joseph A. Maher, Jr.,
MKS's former Vice President and General Manager, Pressure Measurement and
Control Products for the years ended December 31, 2000, 1999 and 1998.


                           SUMMARY COMPENSATION TABLE





                                                                   Other Annual Compensation
                                                           ----------------------------------------    Long-Term
                                                                                                      Compensation
                                                                                                         Awards
                                                                                                      ------------
                                                                                                       Securities
                                                                                       Other Annual    Underlying      All Other
Name and Principal Position                    Year        Salary          Bonus       Compensation    Options(#)   Compensation(1)
---------------------------                    ----        ------          -----       ------------   ------------  ---------------

                                                                                                  
John R. Bertucci .......................       2000       $391,281       $593,372             --             --       $  8,500
Chairman and Chief Executive Officer           1999        348,720        476,957             --             --         12,800
                                               1998        337,440             --             --             --          8,000

Peter R. Younger .......................       2000        241,114        293,448             --         15,000         13,600
President and Chief Operating Officer          1999        138,117        138,114             --        150,000             --


Ronald C. Weigner ......................       2000        196,743        160,871             --         12,000         13,600
Vice President and Chief Financial             1999        187,838        132,517             --             --         12,800
Officer                                        1998        164,257             --             --         60,000          8,000

William D. Stewart .....................       2000        206,135        170,449             --         11,000         13,600
Vice President and General Manager,            1999        191,693        140,225             --             --         12,800
HPS Products                                   1998        173,893             --             --         60,000          8,000

Robert L. Klimm ........................       2000        193,419        161,741             --             --          4,168
Vice President and General Manager,            1999         11,531          8,009             --         75,000             --
Materials Delivery and Analysis Products

Joseph A. Maher, Jr. (2) ...............       2000        201,875        158,165             --          5,500         13,600
Vice President and General Manager,            1999        176,514        132,517             --             --         12,800
Pressure Measurement and Control               1998        161,307             --             --         60,000          8,000
Products


--------------------

(1)  Represents amounts paid into a 401(k) plan. Other compensation in the form
     of perquisites and other personal benefits has been omitted in those
     instances where such perquisites and other personal benefits constituted
     less than the lesser of $50,000 or 10 percent of the total salary and bonus
     for each Named Executive Officer for such year.

(2)  Effective October 13, 2000, Mr. Maher resigned as the Company's Vice
     President and General Manager, Pressure Measurement and Control Products.


                                       15
   19

STOCK OPTION GRANTS


                        OPTION GRANTS IN FISCAL YEAR 2000





                                                                                             Potential Realizable Value at
                                                                                             Assumed Annual Rates of Stock
                                                                                             Price Appreciation for Option
                                Individual Grants                                                       Term(4)
--------------------------------------------------------------------------------------------------------------------------
      (a)                      (b)            (c)            (d)            (e)                (f)                 (g)
                            Number of      % of Total
                           Securities       Options
                           Underlying      Granted to    Exercise or
                            Options       Employees in    Base Price    Expiration
     Name                Granted (#)(1)  Fiscal Year(2)     ($/Sh)        Date(3)               5%                 10%
--------------------------------------------------------------------------------------------------------------------------
                                                                                            
John R. Bertucci ......          --            --               --             --                    --                 --
Peter R. Younger ......      15,000           2.4%         $ 32.00       01/04/10          $ 301,500.00       $ 765,150.00
Ronald C. Weigner .....      12,000           1.9            32.00       01/04/10            241,200.00         612,120.00
William D. Stewart ....      11,000           1.7            32.00       01/04/10            221,100.00         561,110.00
Robert L. Klimm .......          --            --               --             --                    --                 --
Joseph A. Maher, Jr ...       5,500           0.9            32.00       01/04/10            110,550.00         280,555.00



--------------------------
(1)  The Options granted in the fiscal year ended December 31, 2000 are
     exercisable as follows: 25% of the shares become exercisable on the first
     anniversary of the date of issue. An additional 6.25% of the initial grant
     of options vests on each successive quarter.
(2)  In the fiscal year ended December 31, 2000, options to purchase a total of
     637,092 shares of MKS Common Stock were granted to employees of MKS,
     including officers.
(3)  The options are subject to earlier termination upon certain events related
     to termination of employment.
(4)  The dollar gains under these columns result from calculations discussing
     hypothetical growth rates as set by the Commission and are not intended to
     forecast future price appreciation of the Common Stock.



   AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR-END OPTION
                                     VALUES





                                                  Number of Securities Underlying         Value of Unexercised In-the
                                                     Unexercised Options at                     Money Options at
                           Shares                        Fiscal Year End                       Fiscal Year End(1)
                         Acquired on     Value    -----------------------------------------------------------------------
     Name                Exercise (#)  Realized    Exercisable      Unexercisable         Exercisable        Unexercisable
--------------------------------------------------------------------------------------------------------------------------
                                                                                           
John R. Bertucci ......       --          --               --               --                      --                 --
Peter R. Younger ......       --          --           45,000          120,000          $    45,000.00       $ 105,000.00
Ronald C. Weigner .....       --          --          153,600           45,000            1,639,872.00         291,390.00
William D. Stewart ....       --          --          153,600           44,000            1,639,872.00         291,390.00
Robert L. Klimm .......       --          --           15,000           60,000                      --                 --
Joseph A. Maher, Jr ...       --          --          121,950           70,150            1,289,506.50         641,755.50



--------------------------
(1)  Total value of "in-the-money" unexercised options is based on the
     difference between the last sales price of the Company's Common Stock on
     the Nasdaq Stock Market on December 29, 2000 ($15.50 per share) and the
     exercise price of "in-the-money" options, multiplied by the number of
     shares subject to such options.


CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

     Mr. Chute, a director of MKS, MKS's clerk, and co-trustee of certain
Bertucci family trusts and Mr. Thomas H. Belknap, a co-trustee of certain
Bertucci family trusts, are attorneys at the law firm of Hill & Barlow, a
Professional Corporation. Hill & Barlow has provided legal services to MKS
during the calendar year ended December 31, 2000 for which it was compensated by
MKS in the aggregate amount of $286,790.

                                       16
   20

     Mr. Stewart, Vice President and General Manager of the HPS Products group,
is the general partner of Aspen Industrial Park Partnership ("Aspen"). MKS
leases from Aspen certain facilities occupied by MKS's HPS Products group in
Boulder, Colorado. MKS paid Aspen $434,329 in 2000 to lease such facilities.

EMPLOYMENT AGREEMENTS

     MKS entered into employment agreements with each of Messrs. Younger,
Weigner, Stewart, Klimm and Maher. The terms of such employment agreement are
included in the summary below.

     Each agreement sets the base salary for each employee which is reviewed
annually. In addition to a base salary, each employee is entitled, under MKS's
Management Incentive Program, to a bonus equal to a percentage of his base
salary if MKS attains specified financial goals during the year. Each employee
is also entitled to standard benefits including:

     -    participation in a profit sharing and retirement savings plan

     -    vacation days

     -    life insurance

     -    medical/dental insurance

     The remaining provisions of each agreement are also substantially the same.

     The term of employment for each is month to month with termination:

     -    upon the death of the employee

     -    at the election of MKS if the employee fails or refuses to perform

     -    at the election of MKS if the employee commits any acts not in MKS's
          best interest

     Payment by MKS upon termination depends on how employment is terminated:

     -    if employment is terminated by death, MKS must pay the employee's
          estate the compensation owed to him at the end of the month of his
          death

     -    if employment is terminated at the election of MKS because the
          employee fails or refuses to perform, MKS must pay the employee
          through the last day of actual employment

     Each of the agreements contains non-competition provisions during the term
of employment and for the period of one year after termination of employment.
Under these provisions, Messrs. Younger, Weigner, Stewart, Klimm and Maher may
not:

     -    engage in any competitive business or activity

     -    for the 12 months subsequent to termination, work for, employ, become
          a partner with, or cause to be employed, any employee, officer or
          agent of MKS

     -    for the 12 months subsequent to termination, give, sell or lease any
          competitive services or goods to any customer of MKS

     -    have any financial interest in or be a director, officer, stockholder,
          partner, employee or consultant to any competitor of MKS

                                       17
   21

                            SECTION 16(a) BENEFICIAL
                         OWNERSHIP REPORTING COMPLIANCE

     Section 16(a) of the Exchange Act ("Section 16(a)") requires executive
officers, directors, and persons who beneficially own more than ten percent
(10%) of the Company's stock to file initial reports of ownership on Form 3 and
reports of changes in ownership on Form 4 with the Commission and any national
securities exchange on which the Company's securities are registered. Executive
officers, directors and greater than ten percent (10%) beneficial owners are
required by the Commission's regulations to furnish the Company with copies of
all Section 16(a) forms they file.

     Based solely on a review of the copies of such forms furnished to the
Company and written representations from the executive officers and directors,
the Company believes that all of its executive officers, directors and greater
than ten percent (10%) beneficial owners complied with all applicable Section
16(a) filing requirements.

                                       18
   22

COMPARATIVE STOCK PERFORMANCE

     The following graph compares the cumulative total stockholder return
(assuming reinvestment of dividends) from investing $100 on March 30, 1999 (the
Company's first trading day), and plotted at the last trading days of each
fiscal quarter in the years ended December 31, 1999 and 2000, in each of (i) the
Company's Common Stock; (ii) a Peer Group Index of semiconductor
equipment/material manufacturers (the "MG Group Index"), compiled by Media
General Financial Services, Inc. ("Media General"); and (iii) the Nasdaq Market
Index of companies (the "Nasdaq Market Index"). The graph was compiled by Media
General. The stock price performance on the graph below is not necessarily
indicative of future price performance. The Company's Common Stock is listed on
the Nasdaq National Market under the ticker symbol "MKSI".

PERFORMANCE GRAPH


  COMPARISON OF CUMULATIVE TOTAL RETURN OF ONE OR MORE COMPANIES, PEER GROUPS,
                     INDUSTRY INDEXES AND/OR BROAD MARKETS




                                                                      FISCAL QUARTER ENDED
                                --------------------------------------------------------------------------------------------------
                                                                                               
Company/Index/Market            3/30/99    3/31/99    6/30/99     9/30/99    12/31/99   3/31/00    6/30/00     9/30/00    12/31/00
-------------------             -------    -------    -------     -------    --------   -------    -------     -------    --------
MKS INSTRUMENTS, INC.            100.00      95.11     132.44      158.22     256.89     359.11     278.22      194.67     110.22
MG GROUP INDEX                   100.00     100.00     127.86      133.86     219.29     315.68     287.14      186.46     133.76
NASDAQ MARKET INDEX              100.00     100.00     108.81      110.58     163.32     185.83     159.83      147.49      99.12


--------------------------------------------------------------------------------

Note: Base price date is 3/30/1999

                                       19
   23

                                  PROPOSAL TWO

           APPROVAL OF AN AMENDMENT INCREASING AUTHORIZED COMMON STOCK

     On March 13, 2001, the Board of Directors of the Company approved, subject
to stockholder approval, an amendment to the Company's Restated Articles of
Organization increasing the number of authorized shares of Common Stock from
50,000,000 to 75,000,000.

     The authorized Common Stock of the Company currently consists of 50,000,000
shares, no par value, of which (i) 25,604,049 shares were outstanding as of
December 31, 2000 and (ii) 10,060,299 shares were reserved for issuance as of
December 31, 2000 pursuant to the Company's existing stock plans.

     The Board of Directors believes that the authorization of additional shares
of Common Stock is desirable to provide shares for issuance in connection with
the exercise of stock options expected to be granted under the Company's option
and stock purchase plans, and in connection with possible future stock splits,
stock dividends, financings, joint ventures, acquisitions and other general
corporate purposes. Other than as described above, however, there are not
existing plans, understandings or agreements for the issuance of any shares of
Common Stock. If the amendment is adopted by the Company's stockholders, the
Board of Directors will have the authority to issue shares of Common Stock
without the necessity of further stockholder action. The issuance of additional
shares of Common Stock, while providing desirable flexibility in connection with
possible acquisitions and other corporate purposes, would have the effect of
diluting the Company's current stockholders and could have the effect of making
it more difficult for a third party to acquire, or of discouraging a third party
from attempting to acquire, control of the Company. Holders of the Common Stock
have no preemptive rights with respect to any shares which may be issued in the
future.


     THE BOARD OF DIRECTORS BELIEVES THAT THE PROPOSED AMENDMENT IS IN THE BEST
INTERESTS OF THE COMPANY AND ITS STOCKHOLDERS AND THEREFORE RECOMMENDS A VOTE
"FOR" THIS PROPOSAL.


                                 PROPOSAL THREE

                           RATIFICATION OF APPOINTMENT
                           OF INDEPENDENT ACCOUNTANTS

     On March 13, 2001, the Board of Directors, on the recommendation of its
Audit Committee, appointed the firm of PricewaterhouseCoopers LLP ("PwC") as the
Company's independent accountants for the fiscal year of the Company ending
December 31, 2001. PwC was the Company's independent accountants for the fiscal
year ended December 31, 2000.

     Representatives of PwC are expected to be present at the Annual Meeting and
will have the opportunity to make a statement if they so desire and will be
available to respond to appropriate questions from stockholders.

     In the event that the ratification of the appointment of PwC as the
independent accountants for the Company is not obtained at the Annual Meeting,
the Board of Directors will reconsider its appointment.

     THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE PROPOSAL TO RATIFY THE
APPOINTMENT OF PRICEWATERHOUSECOOPERS LLP AS INDEPENDENT ACCOUNTANTS OF THE
COMPANY FOR THE FISCAL YEAR ENDING DECEMBER 31, 2001.

                                       20
   24

                                  OTHER MATTERS

     The Board of Directors does not know of any other matters which may come
before the meeting. However, if any other matters are properly presented to the
meeting, it is the intention of the persons named in the accompanying proxy to
vote, or otherwise act, in accordance with their judgment on such matters.

     All costs of solicitation of proxies will be borne by the Company. In
addition to solicitations by mail, the Company's directors, officers and regular
employees, without additional remuneration, may solicit proxies by telephone,
telegraph and personal interviews and the Company reserves the right to retain
outside agencies for the purpose of soliciting proxies. Brokers, custodians and
fiduciaries will be requested to forward proxy soliciting material to the owners
of stock held in their names, and the Company will reimburse them for their
reasonable out-of-pocket expenses incurred in connection with the distribution
of proxy materials.

                DEADLINE FOR SUBMISSION OF STOCKHOLDER PROPOSALS
                           FOR THE 2002 ANNUAL MEETING

     Proposals of stockholders intended to be presented at the 2002 Annual
Meeting of Stockholders must be received by the Company at its principal office
in Andover, Massachusetts not later than November 30, 2001, for inclusion in the
proxy statement for that meeting.

     In addition, MKS's By-Laws require that MKS be given advance notice of
matters that stockholders wish to present for action at an annual meeting of
stockholders (other than matters included in MKS' proxy statement in accordance
with Rule 14a-8 of the Exchange Act). The required written notice must be
delivered to the Clerk of MKS at the principal offices of MKS at least sixty
(60) days prior to the Annual Meeting, but no more than ninety (90) days prior
to such meeting. However, if less than forty (40) days notice of the Annual
Meeting is provided to the stockholders, the written notice of the stockholder
must be sent to the Clerk of MKS no later than ten (10) days after the notice of
the Annual Meeting was received. The advance notice provisions of MKS's By-Laws
contain the requirements of the written notice of stockholders and supersede the
notice requirement contained in recent amendments to Rule 14a-4 under the
Exchange Act.


                                   By Order of the Board of Directors

                                   /s/ Richard S. Chute
                                   ---------------------------------------------
                                   Richard S. Chute
                                   Clerk


April 10, 2001


     THE BOARD OF DIRECTORS ENCOURAGES STOCKHOLDERS TO ATTEND THE MEETING.
WHETHER OR NOT YOU PLAN TO ATTEND, YOU ARE URGED TO COMPLETE, DATE, SIGN AND
RETURN THE ENCLOSED PROXY IN THE ACCOMPANYING ENVELOPE. A PROMPT RESPONSE WILL
GREATLY FACILITATE ARRANGEMENTS FOR THE MEETING AND YOUR COOPERATION WILL BE
APPRECIATED. STOCKHOLDERS WHO ATTEND THIS MEETING MAY VOTE THEIR STOCK
PERSONALLY EVEN THOUGH THEY HAVE SENT IN THEIR PROXIES.



                                       21
   25
                                                                      APPENDIX A

                                  DETACH HERE

          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

                             MKS INSTRUMENTS, INC.

                      2001 ANNUAL MEETING OF STOCKHOLDERS
                                  MAY 16, 2001


The undersigned stockholder of MKS Instruments, Inc., a Massachusetts
corporation (the "Company"), hereby acknowledges receipt of the Notice of Annual
Meeting of Stockholders and Proxy Statement, each dated April 10, 2001, and
hereby appoints John R. Bertucci and Ronald C. Weigner, and each of them acting
singly, proxies and attorneys-in-fact, with full power to each of substitution,
on behalf and in the name of the undersigned, to represent the undersigned at
the 2001 Annual Meeting of Stockholders of the Company to be held on May 16,
2001, at 10:00 a.m. at the Andover Country Club, 60 Canterbury Street, Andover,
Massachusetts 01810, and at any adjournment(s) thereof, and to vote all shares
of Common Stock which the undersigned would be entitled to vote if then and
there personally present, on the matters set forth on the reverse side, and, in
their discretion, upon any other matters which may properly come before the
meeting.

-----------                                                          -----------
SEE REVERSE        CONTINUED AND TO BE SIGNED ON REVERSE SIDE        SEE REVERSE
   SIDE                                                                 SIDE
-----------                                                          -----------

   26
                                  DETACH HERE

    PLEASE MARK
[X] VOTES AS IN
    THIS EXAMPLE.

This proxy, when properly executed, will be voted as directed below, or, if no
contrary direction is indicated, will be voted FOR the election of the two (2)
nominees listed below as Directors of the Company, FOR proposals 2 and 3 and as
said proxies deem advisable on such other matters as may properly come before
the meeting.

1.  To elect two (2) members of the Board of Directors for a term of three (3)
    years.
    NOMINEES: (01) Owen W. Robbins, (02) Richard S. Chute.

         FOR                       WITHHOLD                    FOR
         ALL     [ ]               FROM ALL     [ ]            ALL      [ ]
       NOMINEES                    NOMINEES                   EXCEPT


--------------------------------------------------------------------------------
(INSTRUCTION: To withhold authority to vote for any individual nominee, mark
"FOR ALL EXCEPT" box and write that nominee's number in the space provided
above.)


                                                      FOR    AGAINST    ABSTAIN
2.  To approve an amendment to the Company's
    Restated Articles of Organization                 [ ]      [ ]        [ ]
    increasing the number of authorized
    shares of Common Stock from 50,000,000
    to 75,000,000.

                                                      FOR    AGAINST    ABSTAIN
3.  To ratify the appointment of
    PricewaterhouseCoopers LLP as independent         [ ]      [ ]        [ ]
    accountants for the Company for the fiscal
    year ending December 31, 2001.

                                                      FOR    AGAINST    ABSTAIN
4.  To transact such other business as may
    properly come before the meeting or any           [ ]      [ ]        [ ]
    postponements or adjournments thereof.

          MARK HERE FOR                           MARK HERE IF
       ADDRESS CHANGE AND    [ ]               YOU PLAN TO ATTEND     [ ]
           NOTE BELOW                             THE MEETING

TO ENSURE YOUR REPRESENTATION AT THE ANNUAL MEETING, PLEASE MARK, SIGN AND DATE
THIS PROXY AND RETURN IT AS PROMPTLY AS POSSIBLE.

(This proxy should be marked, dated and signed by the stockholder(s) exactly as
his or her name appears hereon, and returned promptly in the enclosed envelope.
When shares and held by joint tenants, both should sign. When signing as
attorney, as executor, administrator, trustee or guardian, please give full
title as such. If a corporation, please sign in full corporate name by president
or other authorized officer. If a partnership, please sign in partnership name
by authorized person, who should state his or her title.)

Signature:                  Date:       Signature:                  Date:
          ------------------     -------          ------------------     -------
   27

                                                                      APPENDIX B

                              MKS INSTRUMENTS, INC.
                             AUDIT COMMITTEE CHARTER


PURPOSE

The primary purpose of the Audit Committee (the "Committee") is to assist the
Board of Directors (the "Board") in fulfilling its responsibility to oversee
management's conduct of the Company's financial reporting process, including by
overviewing the financial reports and other financial information provided by
the Company to any governmental or regulatory body, the public or other users
thereof, the Company's systems of internal accounting and financial controls,
and the annual independent audit of the Company's financial statements.

In discharging its oversight role, the Committee is empowered to investigate any
matter brought to its attention with full access to all books, records,
facilities and personnel of the Company and the power to retain outside counsel,
auditors or other experts for this purpose. The Board and the Committee are in
place to represent the Company's shareholders; accordingly, the outside auditor
is ultimately accountable to the Board and the Committee.

The Committee shall review the adequacy of this Charter on an annual basis.


MEMBERSHIP

The Committee shall be comprised of not less than three members of the Board,
and the Committee's composition will meet the requirements of the Audit
Committee Policy of the NASD.

Accordingly, all of the members will be directors:

1.   Who have no relationship to the Company that may interfere with the
     exercise of their independence from management and the Company;

2.   Who are able to read and understand fundamental financial statements,
     including the Company's balance sheet, income statement, and cash flow
     statement, or must become able to do so within a reasonable time after his
     or her appointment to the Committee. At least one member of the Committee
     must have past employment experience in finance or accounting, professional
     certification in accounting, or other comparable experience or background
     which result in the member having financial sophistication (such as being
     or having been a chief executive officer, chief financial officer or other
     senior officer with financial oversight responsibilities);

3.   Who have not been an employee of the Company or any affiliate of the
     Company in the current year or in any of the past three years;

4.   Who have no immediate family member who has been employed by the Company or
     an affiliate of the Company in any of the past three years (an immediate
     family member includes a person's spouse, parents, children, siblings,
     mother-in-law, father-in-law, brother-in-law, sister-in-law, son-in-law,
     daughter-in-law, and anyone who resides in a person's home);

5.   Who is not employed as an executive of an entity other than the Company
     having a compensation committee which includes any of the Company's
     executives;

                                      B-1
   28

6.   Who did not within the last fiscal year receive from the Company or any
     affiliate of the Company compensation - other than benefits under a tax
     qualified retirement plan, compensation for director service or
     nondiscretionary compensation - greater than $60,000; and

7.   Who has not in any of the past three years been a partner in, or
     controlling shareholder or executive of, a for profit business organization
     to which the Company made or from which the Company received payment (other
     than payment arising solely from investments in the Company's securities)
     that exceeds the greater of: (i) $200,000; or (ii) more than 5% of the
     Company's or business organization's consolidated gross revenues.


KEY RESPONSIBILITIES

The Committee's job is one of oversight and it recognizes that the Company's
management is responsible for preparing the Company's financial statements and
that the outside auditors are responsible for auditing those financial
statements. Additionally, the Committee recognizes that financial management, as
well as the outside auditors, have more time, knowledge and more detailed
information on the Company than do Committee members; consequently, in carrying
out its oversight responsibilities, the Committee is not providing any expert or
special assurance as to the Company's financial statements or any professional
certification as to the outside auditor's work.

The following functions shall be the common recurring activities of the
Committee in carrying out its oversight function. These functions are set forth
as a guide with the understanding that the Committee may diverge from this guide
as appropriate given the circumstances.

-    The Committee shall review with management and the outside auditors the
     audited financial statements to be included in the Company's Annual Report
     on Form 10-K (or the Annual Report to Shareholders if distributed prior to
     the filing of Form 10-K) and review and consider with the outside auditors
     the matters required to be discussed by Statement of Auditing Standards
     ("SAS") No. 61.

-    As a whole, or through the Committee chair, the Committee shall review with
     the outside auditors the matters (if any) required to be discussed by SAS
     No. 61 in connection with the interim financial reviews conducted by the
     outside auditors; this review will occur prior to the Company's filing of
     the Form 10-Q.

-    The Committee shall discuss with management and the outside auditors the
     quality and adequacy of the Company's internal controls, accounting
     policies and estimates.

-    The Committee shall review and reassess the adequacy of this Charter at
     least annually.

-    The Committee shall:

     -    request from the outside auditors annually, a formal written statement
          delineating all relationships between the auditor and the Company
          consistent with Independence Standards Board Standard Number 1;

     -    discuss with the outside auditors any such disclosed relationships or
          services and their impact on the outside auditor's independence; and

     -    recommend that the Board take appropriate action to oversee the
          independence of the outside auditor.

                                      B-2
   29

-    The Committee, subject to any action that may be taken by the Board, shall
     have the ultimate authority and responsibility to select (or nominate for
     shareholder approval), evaluate and, where appropriate, replace the outside
     auditor.

-    The Committee will prepare the report required by the rules of the
     Securities and Exchange Commission to be included in the Company's annual
     proxy statement, commencing with the proxy statement for the 2001 Annual
     Meeting.

-    Based on the criteria set forth in Item 306(a) of Regulation S-K and, if so
     determined by the Committee, recommend to the Board that the audited
     financial statements for each fiscal year be included in the Company's
     Annual Report on Form 10-K in respect of such year.

-    The Committee will perform such other functions as may be required by law,
     the Company's Articles of Organization or its By-Laws.

-    The Committee shall annually inform the outside auditor, the Chief
     Financial Officer, the Controller, and the most senior other person, if
     any, responsible for the internal audit activities, that they should
     promptly contact the Committee or its Chairman about any significant issue
     or disagreement concerning the Company's accounting practices or financial
     statements that is not resolved to their satisfaction. Where such
     communications are made to the Chairman, he or she shall confer with the
     outside auditor concerning any such communications, and shall notify the
     other members of the Committee of any communications which the outside
     auditor or the Chairman in the exercise of his or her business judgment
     believes should be considered by the Committee prior to its next scheduled
     meeting.

-    The Committee shall direct the outside auditor to use its best efforts to
     perform all reviews of interim financial information prior to disclosure by
     the Company of such information, and to discuss promptly with the Chairman
     of the Committee and the Chief Financial Officer any matters identified in
     connection with the auditor's review of interim financial information which
     are required to be discussed by Statement on Auditing Standards No. 61. The
     Chairman of the Committee shall discuss any such matters with the outside
     auditor, and shall notify the other members of the Committee of any
     discussions which the outside auditor or the Chairman in the exercise of
     his or her business judgment believes should be considered by the Committee
     prior to disclosure or filing of the interim financial information, or the
     Committee's next scheduled meeting.

-    The Committee shall direct management to advise the Committee in the event
     that the Company proposes to disclose or file interim financial information
     prior to completion of review by the outside auditor.

-    The Committee shall meet privately at least once per year with: (i) the
     outside auditor; (ii) the Chief Financial Officer; (iii) the Controller;
     and (iv) the most senior person (if any) responsible for the internal audit
     activities of the Company.


                                       B-3