UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 5 ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP [ ] Check box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. [ ] Form 3 Holdings Reported [ ] Form 4 Transactions Reported 1. Name and Address of Reporting Person(s) Grimm, Donald W 1600 Faraday Avenue Carlsbad, CA 92008 2. Issuer Name and Ticker or Trading Symbol Invitrogen Corporation (IVGN) 3. I.R.S. Identification Number of Reporting Person, if an entity (Voluntary) 4. Statement for Month/Year 12/02 5. If Amendment, Date of Original (Month/Year) 6. Relationship of Reporting Person(s) to Issuer (Check all applicable) [X] Director [ ] 10% Owner [ ] Officer (give title below) [ ] Other (specify below) Board Director 7. Individual or Joint/Group Filing (Check Applicable Line) [X] Form filed by One Reporting Person [ ] Form filed by More than One Reporting Person Table I Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Security 2)Trans- 3.Trans- 4.Securities Acquired(A) 5)Amount of 6) 7)Nature of action action or Disposed of (D) Securities Indirect Date Code A Beneficially D Beneficial (Month/ or Owned at or Ownership Day/Year) Code Amount D Price End of Year I ------------------------------------------------------------------------------------------------------------------------------------ Common Stock 3,000 D Direct Table II (PART 1) Derivative Securitites Acquired, Disposed of, or Beneficially Owned (Columns 1 through 6) ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Derivative 2)Conversion 3)Trans- 4)Trans- 5)Number of Derivative 6)Date Exercisable and Security or Exercise action action Securities Acquired (A) Expiration Date Price of Date Code or Disposed of (D) Derivative Security Code A D Exercisable Expiration ------------------------------------------------------------------------------------------------------------------------------------ Non-Qualified Stock Option $12.0000 01/16/00 01/15/10 (right to buy) Non-Qualified Stock Option $5.6000 05/28/99 05/28/08 (right to buy) Non-Qualified Stock Option $35.1200 05/24/02 A 10,000 05/24/03 05/24/12 (right to buy) Non-Qualified Stock Option $57.8750 04/27/01 04/27/10 (right to buy) Non-Qualified Stock Option $66.6200 04/27/02 04/27/11 (right to buy) Table II (PART 2) Derivative Securitites Acquired, Disposed of, or Beneficially Owned (Columns 1,3 and 7 through 11) ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Derivative 3)Trans- 7)Title and Amount 8)Price 9)Number of 10) 11)Nature of Security action of Underlying of Deri- Derivative Indirect Date Securities vative Securities D Beneficial Amount or Security Beneficially or Ownership Number of Owned at I - Title Shares End of Year ------------------------------------------------------------------------------------------------------------------------------------ Non-Qualified Stock Option Common Stock 10,000 10,000 D Direct (right to buy) Non-Qualified Stock Option Common Stock 10,000 10,000 D Direct (right to buy) Non-Qualified Stock Option 05/24/02 Common Stock 10,000 10,000 D Direct (right to buy) Non-Qualified Stock Option Common Stock 10,000 10,000 D Direct (right to buy) Non-Qualified Stock Option Common Stock 10,000 10,000 D Direct (right to buy)Explanation of Responses: SIGNATURE OF REPORTING PERSON /S/ By: Cheri L. Manis For: Donald W Grimm DATE 02/05/03