UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                                (Amendment No. )*

                          EMISPHERE TECHNOLOGIES, INC.
                          ----------------------------
                                (Name of Issuer)

                     Common Stock, par value $.01 per share
                     --------------------------------------
                         (Title of Class of Securities)

                                    291345106
                                    ---------
                                 (CUSIP Number)

                                 March 31, 2005
                                 --------------
                      (Date of Event which Requires Filing
                               of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

        [ ] Rule 13d-1(b) 
        [X] Rule 13d-1(c) 
        [ ] Rule 13d-1(d)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                          Continued on following pages
                               Page 1 of 10 Pages
                              Exhibit Index: Page 9






                                  SCHEDULE 13G

CUSIP No. 291345106                                            Page 2 of 9 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only)

                  MHR CAPITAL PARTNERS LP

2        Check the Appropriate Box If a Member of a Group (See Instructions)

                                              a. [ ]
                                              b. [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                      5        Sole Voting Power
 Number of                              3,680,123
  Shares
Beneficially          6        Shared Voting Power
  Owned By                              0
   Each
 Reporting            7        Sole Dispositive Power
   Person                               3,680,123
   With
                      8        Shared Dispositive Power
                                        0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                           3,680,123

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares (See Instructions)

                           [X]

11       Percent of Class Represented By Amount in Row (9)

                           15.32%

12       Type of Reporting Person (See Instructions)

                           PN


                                  SCHEDULE 13G

CUSIP No. 291345106                                            Page 3 of 9 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only)

                  MHR ADVISORS LLC

2        Check the Appropriate Box If a Member of a Group (See Instructions)

                                              a. [ ]
                                              b. [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                      5        Sole Voting Power
 Number of                              4,187,501
  Shares
Beneficially          6        Shared Voting Power
  Owned By                              0
   Each
 Reporting            7        Sole Dispositive Power
   Person                               4,187,501
   With
                      8        Shared Dispositive Power
                                        0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                           4,187,501

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares (See Instructions)

                           [ ]

11       Percent of Class Represented By Amount in Row (9)

                           17.35%

12       Type of Reporting Person (See Instructions)

                           OO





                                  SCHEDULE 13G

CUSIP No. 291345106                                            Page 4 of 9 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only)

                  MARK H. RACHESKY, M.D.

2        Check the Appropriate Box If a Member of a Group (See Instructions)

                                              a. [ ]
                                              b. [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  UNITED STATES

                      5        Sole Voting Power
 Number of                              4,187,501
  Shares
Beneficially          6        Shared Voting Power
  Owned By                              0
   Each
 Reporting            7        Sole Dispositive Power
   Person                               4,187,501
   With
                      8        Shared Dispositive Power
                                        0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                           4,187,501

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares (See Instructions)

                           [ ]

11       Percent of Class Represented By Amount in Row (9)

                           17.35%

12       Type of Reporting Person (See Instructions)

                           IA




                                                              Page 5 of 10 Pages


Item 1(a)         Name of Issuer:

                  Emisphere Technologies, Inc. (the "Issuer")

Item 1(b)         Address of the Issuer's Principal Executive Offices:

                  765 Old Saw Mill River Road, Tarrytown, New York 10591

Item 2(a)         Name of Person Filing:

                  The  Statement  is filed on  behalf  of each of the  following
persons (collectively, the "Reporting Persons"):

                  i)   MHR Capital Partners LP ("Capital Partners");

                  ii)  MHR Advisors LLC ("Advisors"); and

                  iii) Mark H. Rachesky, M.D. ("Dr. Rachesky").

                  This Statement  relates to securities held for the accounts of
each of Capital  Partners and MHR Capital  Partners (100) LP, a Delaware limited
partnership ("Capital Partners (100)").  Advisors is the general partner of each
of Capital  Partners and Capital  Partners (100) and, in such  capacity,  may be
deemed to  beneficially  own the  securities  held for the  accounts  of each of
Capital Partners and Capital Partners (100). Dr. Rachesky is the managing member
of  Advisors  and,  in such  capacity,  may be  deemed to  beneficially  own the
securities  held  for the  accounts  of each of  Capital  Partners  and  Capital
Partners (100).

Item 2(b)         Address of Principal Business Office or, if None, Residence:

                  The  address  of the  principal  business  office  of  each of
Capital Partners,  Advisors and Dr. Rachesky is 40 West 57th Street, 24th Floor,
New York, New York 10019.

Item 2(c)         Citizenship:

                  i)   Capital Partners is a Delaware limited partnership;

                  ii)  Advisors is a Delaware limited liability company; and

                  iii) Dr. Rachesky is a United States citizen.

Item 2(d)         Title of Class of Securities:

                  Common Stock, par value $.01 per share

Item 2(e)         CUSIP Number:

                  291345106




                                                              Page 6 of 10 Pages


Item 3.           If this statement is filed pursuant to Rule 13d-1(b), or 
                  13d-2(b) or (c), check whether the person filing is a:

                  This Item 3 is not applicable.

Item 4.           Ownership:

Item 4(a)         Amount Beneficially Owned:

                  As of the date hereof,

                  i) Capital  Partners may be deemed to be the beneficial  owner
of  3,680,123  Shares.  This number  consists of  2,856,736  Shares held for the
account of Capital  Partners and 823,387  Shares  issuable  upon the exercise of
warrants held for the account of Capital Partners.

                  ii) Each of Advisors and Dr.  Rachesky may be deemed to be the
beneficial  owner of an aggregate  of 4,187,501  Shares held for the accounts of
each of Capital Partners and Capital Partners (100).  This number consists of A)
2,856,736  Shares held for the account of Capital  Partners,  B) 823,387  Shares
issuable upon the exercise of warrants held for the account of Capital Partners,
C) 393,264 Shares held for the account of Capital Partners (100), and D) 114,114
Shares  issuable  upon the exercise of warrants  held for the account of Capital
Partners (100).

Item 4(b)         Percent of Class:

                  The  percentages  set forth below are calculated  based on the
assumption that the Issuer has  approximately  23,201,522 Shares of common stock
issued and outstanding as of the date hereof.

                  i) The number of Shares of which each of Capital  Partners may
be deemed to be the beneficial  owner  constitutes  approximately  15.32% of the
total number of Shares outstanding.

                  ii) The  number of Shares of which  each of  Advisors  and Dr.
Rachesky  may be deemed to be the  beneficial  owner  constitutes  approximately
17.35% of the total number of Shares outstanding.

Item 4(c)         Number of shares as to which such person has:

         Capital Partners
         ----------------
         (i)       Sole power to vote or direct the vote:              3,680,123

         (ii)      Shared power to vote or to direct the vote:                 0

         (iii)     Sole power to dispose or to direct the 
                   disposition of:                                     3,680,123

         (iv)      Shared power to dispose or to direct the 
                   disposition of:                                             0

         Advisors
         --------
         (i)       Sole power to vote or direct the vote:              4,187,501

         (ii)      Shared power to vote or to direct the vote:                 0

         (iii)     Sole power to dispose or to direct the 
                   disposition of:                                     4,187,501

         (iv)      Shared power to dispose or to direct the 
                   disposition of:                                             0



                                                              Page 7 of 10 Pages


         Dr. Rachesky
         ------------
         (i)       Sole power to vote or direct the vote:              4,187,501

         (ii)      Shared power to vote or to direct the vote:                 0

         (iii)     Sole power to dispose or to direct the 
                   disposition of:                                     4,187,501

         (iv)      Shared power to dispose or to direct the 
                   disposition of:                                             0

Item 5.           Ownership of Five Percent or Less of a Class:

                  This Item 5 is not applicable.

Item 6.           Ownership of More than Five Percent on Behalf of Another 
                  Person:

                  The partners of each of Capital  Partners and Capital Partners
(100),  including  Advisors,  have the right to  participate  in the  receipt of
dividends  from,  or  proceeds  from the sale of,  the  securities  held for the
accounts of each of Capital  Partners and Capital  Partners  (100) in accordance
with their  respective  ownership  interests  in Capital  Partners  and  Capital
Partners (100).

Item 7.           Identification and Classification of the Subsidiary Which 
                  Acquired the Security Being Reported on by the Parent Holding 
                  Company:

                  This Item 7 is not applicable.

Item 8.           Identification and Classification of Members of the Group:

                  This Item 8 is not applicable.

Item 9.           Notice of Dissolution of Group:

                  This Item 9 is not applicable.

Item 10.          Certification:

                  By signing below each signatory certifies that, to the best of
his/its knowledge and belief, the securities referred to above were not acquired
and  are  not  held  for the  purpose  of or with  the  effect  of  changing  or
influencing  the control of the Issuer of such  securities and were not acquired
and are not  held in  connection  with or as a  participant  in any  transaction
having such purpose or effect.




Page 8 of 10 Pages


                                   SIGNATURES


     After  reasonable  inquiry and to the best of my knowledge and belief,  the
undersigned  certifies that the information set forth in this statement is true,
complete and correct.

Date:  April 8, 2005                          MHR CAPITAL PARTNERS LP

                                              By:   MHR Advisors LLC,
                                                    its General Partner

                                              By:   /s/ Hal Goldstein
                                                    ----------------------------
                                                    Hal Goldstein,
                                                    Vice President


                                              MHR ADVISORS LLC

                                              By:   /s/ Hal Goldstein
                                                    ----------------------------
                                                    Hal Goldstein
                                                    Vice President


                                              MARK H. RACHESKY, M.D.


                                              By:   /s/ Mark H. Rachesky, M.D.
                                                    ----------------------------




                                                              Page 9 of 10 Pages


                                  EXHIBIT INDEX

                                                                        Page No.
                                                                        --------

A.      Joint Filing Agreement, dated as of April 8, 2005, by
        and among MHR Capital Partners LP, MHR Advisors LLC
        and Mark H. Rachesky, M.D.............................                10





                                                             Page 10 of 10 Pages


                                    EXHIBIT A

                             JOINT FILING AGREEMENT

     The  undersigned  hereby agree that this Initial  Statement on Schedule 13G
with respect to the common stock of Emisphere  Technologies,  Inc.,  dated as of
April 8, 2005, is, and any amendments thereto (including  amendments on Schedule
13D) signed by each of the  undersigned  shall be, filed on behalf of each of us
pursuant to and in accordance  with the  provisions  of Rule 13d-1(k)  under the
Securities Exchange Act of 1934.


Date:  April 8, 2005                          MHR CAPITAL PARTNERS LP

                                              By:   MHR Advisors LLC,
                                                    its General Partner

                                              By:   /s/ Hal Goldstein
                                                    ----------------------------
                                                    Hal Goldstein,
                                                    Vice President


                                              MHR ADVISORS LLC

                                              By:   /s/ Hal Goldstein
                                                    ----------------------------
                                                    Hal Goldstein
                                                    Vice President


                                              MARK H. RACHESKY, M.D.


                                              By:   /s/ Mark H. Rachesky, M.D.
                                                    ----------------------------