Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
RACHESKY MARK H MD
  2. Issuer Name and Ticker or Trading Symbol
EMISPHERE TECHNOLOGIES INC [EMIS]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
40 WEST 57TH STREET,, 24TH FLOOR
3. Date of Earliest Transaction (Month/Day/Year)
01/30/2006
(Street)

NEW YORK, NY 10019
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Exchange- able Secured Loan (1) $ 3.78 01/30/2006   J   $ 3,036,203   01/30/2006 09/26/2012 Common Stock 803,228 (1) $ 3,036,203 I See attached footnote (2)
Exchange- able Secured Loan (1) $ 3.78 01/30/2006   J   $ 415,208   01/30/2006 09/26/2012 Common Stock 109,843 (1) $ 415,208 I See attached footnote (3)
Exchange-able Secured Loan (1) $ 3.78 01/30/2006   J   $ 3,303,638   01/30/2006 09/26/2012 Common Stock 873,978 (1) $ 3,303,638 I See attached footnote (4)
Exchange- able Secured Loan (1) $ 3.78 01/30/2006   J   $ 8,322,868   01/30/2006 09/26/2012 Common Stock 2,201,817 (1) $ 8,322,868 I See footnote (5)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
RACHESKY MARK H MD
40 WEST 57TH STREET,
24TH FLOOR
NEW YORK, NY 10019
  X   X    
MHR ADVISORS LLC
40 WEST 57TH STREET, 24TH FLOOR
NEW YORK
NY, NY 10019
    X    
MHR CAPITAL PARTNERS (500) LP
40 WEST 57TH STREET, 24TH FLOOR
NEW YORK, NY 10019
    X    

Signatures

 /s/ Mark H. Rachesky   02/01/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Commencing on January 30, 2006, the Reporting Persons became entitled to exchange a secured loan make to the Issuer into convertible notes of the Issuer on a dollar-for-dollar basis. If the securred loan is exchanged for convertible notes, additional shares of the Issuer's common stock may be issuable upon the subsequent conversion of the convertible notes into shares of the Issuer's common stock as the convertible notes pay interest in-kind by the delivery of additional convertible notes to the holders thereof. As of the date of the filing of this Form 4, the secured loan has not been exchanged into convertible notes.
(2) These securities are held for the account of MHR Capital Partners (500) LP (f/k/a MHR Capital Partners LP), a Delaware limited partnership ("Capital Partners (500)"). MHR Advisors LLC, a Delaware limited liability company ("Advisors"), is the general partner of Capital Partners (500). Mark H. Rachesky, M.D. ("Dr Rachesky") is the managing member of Advisors. In such capacityl Dr. Rachesky may be deemed to be the beneficial owner of the securities held for the account of Capital Partners (500).
(3) These securities are held for the account of MHR Capital Partners (100) LP, a Delaware limited partnership ("Capital Partners (100)"). Advisors is the general partner of Capital Partners (100). Dr. Rachesky is the managing member of Advisors. In such capacity, Dr. Rachesky may be deemed to be the beneficial owner of the securities held for the account of Capital Partners (100).
(4) These securities are held for the account of MHR Institutional Partners II LP, a Delaware limited partnership ("Institutional Partners II"). MHR Institutional Advisors II LLC, a Delaware limited liability company ("Advisors II"), is the general partner of Institutional Parnters II. Dr. Rachesky is the managing member of Advisors II. In such capacity, Dr. Rachesky may be deemed to be the beneficial owner of the securities held for the account of Institutional Partners II.
(5) These securities are held for the account of MHR Institutional Partners IIA LP, a Delaware limited partnership ("Institutional Partners IIA"). Advisors II is the general partner of Institutional Partners IIA. Dr. Rachesky is the managing member of Advisors II. In such capacity, Dr. Rachesky may be deemed to be the beneficial owner of the securities held for the account of Institutional Partners IIA.
 
Remarks:
Remarks:
The filing of this statement shall not be deemed an admission that any of the Reporting Persons is the beneficial owner of any securities not held directly for his or its account for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise.


Exhibit List:
Exhibit 99-Joint Filer Information

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