FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * MOTTO WILLIAM J   2. Issuer Name and Ticker or Trading Symbol MERIDIAN BIOSCIENCE INC [VIVO] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director __X__ 10% Owner __X__ Officer (give title below) _____ Other (specify below) Chairman, CEO (Last) (First) (Middle) MERIDIAN BIOSCIENCE, INC, 3471 RIVER HILLS DRIVE 3. Date of Earliest Transaction (Month/Day/Year) 09/21/2005 (Street) CINCINNATI, OH 45244 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12/23/2004   G V 12,600 (3) D $ 0 562,500 (3) D   Common Stock               144,750 (3) I By Trust (2) Common Stock 09/21/2005   S   1,500,000 (3) (6) D $ 17.5 (7) 300,000 (3) (4) I By Trust (5) Common Stock               2,368,156 (3) (4) I By partnership (1)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
MOTTO WILLIAM J MERIDIAN BIOSCIENCE, INC 3471 RIVER HILLS DRIVE CINCINNATI, OH 45244	X	X	Chairman, CEO

Signatures

Melissa Lueke, Attorney-in-Fact for William J. Motto		09/22/2005
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The sole general partner of this limited partnership, Motto Vivo Family Limited Partnership, is Motto Management, LLC, which holds 1% of the Limited Partnership. (The 100% owner of Motto Management, LLC is William J. Motto and David H. Motto, Trustees under the William J. Motto Revocable Trust.) The only other limited partner is William J. Motto and David H. Motto, Trustees under the William J. Motto Revocable Trust. Mr. Motto disclaims beneficial ownership of Meridian's common stock held by the Limited Partnership except to the extent of his pecuniary interest therein.
(2)	Shares held by the William J. Motto Irrevocable Family Trust. Mr. Motto disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.
(3)	Adjusted to reflect a 3-for-2 stock split by the Company effective September 2, 2005.
(4)	Share totals updated to reflect prior transfer of shares without consideration from the Motto Vivo Family Limited Partnership to an irrevocable trust over which Mr. Motto maintains beneficial ownership.
(5)	Shares held by an irrevocable trust over which Mr. Motto maintains beneficial ownership.
(6)	Shares sold in a public offering pursuant to an underwriting agreement dated September 16, 2005, under which the sale of shares was consummated on September 21, 2005.
(7)	Represents the price to public in the underwritten public offering and excludes underwriting discounts of $0.875 per share.

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