OMB APPROVAL OMB Number: 3235-0578 Expires: April 30, 2010 Estimated average burden hours per response..... 10.5 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM N-Q CERTIFIED SHAREHOLDER REPORT OF REGISTERED MANAGEMENT INVESTMENT COMPANIES Investment Company Act file number 811-21409 Pioneer Municipal High Income Advantage Trust (Exact name of registrant as specified in charter) 60 State Street, Boston, MA 02109 (Address of principal executive offices) (ZIP code) Dorothy E. Bourassa, Pioneer Investment Management, Inc., 60 State Street, Boston, MA 02109 (Name and address of agent for service) Registrant's telephone number, including area code: (617) 742-7825 Date of fiscal year end: March 31 Date of reporting period: June 30, 2008 Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after close of the first and third fiscal quarters, pursuant to Rule 30b1-5under the Investment Company Act of 1940 (17 CFR 270.30b-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles. A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget ("OMB") control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. ss. 3507. ITEM 1. Schedule of Investments. Pioneer Municipal High Income Advantage Trust SCHEDULE OF INVESTMENTS 6/30/08 (unaudited) Principal Amount Value ($) ($) TAX-EXEMPT OBLIGATIONS - 140.3% of Net Assets Arizona - 4.3% 5,000,000 Casa Grande Industrial Development Authority, Hospital 5,000,500 1,000,000 Pima County Industrial Development Authority, 6.3%, 7/1 972,810 1,551,000 Pima County Industrial Development Authority, 6.75%, 7/ 1,561,841 2,640,000 Pima County Industrial Development Authority, 7.0%, 1/1 2,492,978 1,000,000 + Pima County Industrial Development Authority, 7.5%, 7/1 1,183,970 2,000,000 San Luis Facility Development Corp., 7.25%, 5/1/27 1,794,020 13,006,119 California - 11.1% 2,680,000 + Golden State Tobacco Securitization Corp., 6.75%, 6/1/3 3,036,467 8,170,000 (a)Lehman Municipal Trust Receipts, RIB, 11.121%, 6/1/37 ( 8,326,864 3,140,000 (a)Lehman Municipal Trust Receipts, RIB, 11.451%, 11/1/39 3,299,606 2,500,000 San Jose California Airport Revenue, 5.0%, 3/1/37 2,433,000 9,520,000 (a)University of California, RIB, 11.757%, 5/15/38 (144A) 9,745,814 9,015,000 Valley Health System Hospital Revenue, 6.875%, 5/15/23 6,610,699 33,452,450 Colorado - 2.3% 2,850,000 + Denver Health & Hospital Authority Healthcare Revenue, 3,105,103 3,520,000 + Northwest Parkway Public Highway Authority, 7.125%, 6/1 3,940,253 7,045,356 District of Columbia - 2.2% 2,700,000 District of Columbia Tobacco Settlement Financing Corp. 2,594,754 4,000,000 District of Columbia Tobacco Settlement Financing Corp. 4,010,360 6,605,114 Florida - 5.5% 1,000,000 Greater Orlando Aviation Authority, 6.5%, 11/15/36 706,750 4,500,000 Hillsborough County Florida Industrial Development Authority Pollution Control Revenue, 5.5%, 10/1/23 4,408,650 1,980,000 Hillsborough County Florida Industrial Development Authority Pollution Control Revenue, 6.75%, 7/1/29 1,923,827 6,890,000 (a)Lehman Municipal Trust Receipts, RIB, 11.619%, 7/1/37 ( 7,456,565 500,000 Miami Beach Health Facilities Authority, 5.375%, 11/15/ 434,640 1,500,000 Miami Beach Health Facilities Authority, 6.7%, 11/15/19 1,529,250 16,459,682 Georgia - 7.0% 4,000,000 (a)Atlanta Georgia Water and Wastewater Revenue, RIB, 11.9 3,977,440 1,065,000 Effingham County Industrial Development Authority, 6.5% 979,395 3,360,000 Fulton County Residential Care Facilities, 7.0%, 7/1/29 2,850,086 7,500,000 Main Street Natural Gas, Inc., Gas Project Revenue Bond 7,153,800 4,500,000 Main Street Natural Gas, Inc., Gas Project Revenue Bond 4,317,300 1,650,000 Savannah Georgia Economic Development Authority Revenue 1,694,781 20,972,802 Guam - 2.7% 3,000,000 Northern Mariana Islands, 5.0%, 6/1/30 2,459,760 4,600,000 + Northern Mariana Islands, 6.75%, 10/1/33 5,234,708 400,000 Northern Mariana Islands, 6.75%, 10/1/33 405,932 8,100,400 Idaho - 2.6% 2,000,000 Power County Industrial Development Corp., 6.45%, 8/1/3 1,992,580 5,920,000 Power County Pollution Control Revenue, 5.625% 10/1/14 5,948,179 7,940,759 Illinois - 5.9% 4,000,000 Centerpoint Intermodal Center, 8.0%, 6/15/23 (144A) 3,699,640 1,100,000 Illinois Finance Authority Revenue, 5.5%, 5/15/26 964,590 2,350,000 Illinois Finance Authority Revenue, 5.75%, 5/15/38 2,003,211 1,000,000 Illinois Finance Authority Revenue, 6.0%, 11/15/27 922,540 3,000,000 Illinois Finance Authority Revenue, 6.0%, 11/15/39 2,658,450 2,500,000 Illinois Finance Authority Revenue, 6.125%, 11/15/25 2,330,450 1,645,000 Illinois Health Facilities Authority Revenue, 5.5%, 11/ 1,489,449 1,500,000 Illinois Health Facilities Authority Revenue, 6.9%, 11/ 1,288,950 2,700,000 Southwestern Illinois Development Authority Revenue, 5. 2,384,235 17,741,515 Indiana - 5.3% 10,000,000 Indiana State Development Finance Authority Revenue, 5.10,120,000 5,000,000 Jasper County Industrial Economic Development Revenue, 3,945,950 2,170,000 Vincennes Industrial Economic Development Revenue, 6.25 1,967,843 16,033,793 Kentucky - 1.5% 500,000 Kentucky Economic Development Finance Authority Hospita 496,105 4,400,000 Kentucky Economic Development Finance Authority Hospita 4,059,968 4,556,073 Louisiana - 4.0% 2,500,000 Louisiana Local Government Environmental Facilities Dev 2,490,225 750,000 Opelousas Louisiana General Hospital Authority Revenue, 760,920 9,415,000 Tobacco Settlement Financing Corp., 5.875%, 5/15/39 8,728,552 11,979,697 Maryland - 0.5% 710,000 Maryland Health & Higher Educational Facilities Authori 602,733 1,250,000 Maryland Health & Higher Educational Facilities Authori 1,007,050 1,609,783 Massachusetts - 4.8% 2,195,000 Massachusetts Health & Educational Facilities Authority 2,048,308 1,000,000 + Massachusetts Health & Educational Facilities Authority 1,117,140 900,000 Massachusetts State Development Finance Agency, 5.25%, 807,318 2,920,000 Massachusetts State Development Finance Agency, 6.0%, 1 2,743,720 4,540,000 Massachusetts State Development Finance Agency, 7.1%, 7 4,574,005 3,335,000 (a)Massachusetts State Housing Finance Agency, RIB, 11.947 3,097,481 14,387,972 Michigan - 3.9% 1,650,000 Crescent Academy Project Full Term Certificates of Part 1,237,203 1,500,000 + Delta County Michigan Economic Development Corp., 6.25% 1,651,740 3,000,000 Macomb County Hospital Finance Authority Revenue, 5.875 2,755,140 4,130,000 Michigan State Hospital Finance Authority Revenue, 5.5% 3,784,071 1,000,000 Michigan State Strategic Fund Solid Waste Disposal Reve 1,006,570 1,470,000 Star International Academy Full Term Certificates of Pa 1,316,606 11,751,330 Missouri - 3.0% 1,850,000 Kansas City Industrial Development Authority Revenue, 5 1,625,281 1,500,000 St. Louis Industrial Development Authority Revenue, 7.2 1,374,450 6,640,000 St. Louis Industrial Development Authority Revenue, 7.2 6,096,250 9,095,981 Montana - 0.8% 2,445,000 (b)Hardin Increment Industrial Infrastructure Development 1,541,988 1,000,000 Two Rivers Authority, Inc., Project Revenue, 7.375%, 11 725,590 2,267,578 Nevada - 1.0% 2,425,000 Clark County Industrial Development Revenue, 5.5%, 10/1 2,090,617 1,600,000 Nevada State Department of Business & Industry, 7.25%, 477,984 1,000,000 Nevada State Department of Business & Industry, 7.375%, 298,660 70,000 Nevada State Department of Business & Industry, 7.375%, 20,907 2,888,168 New Hampshire - 0.6% 1,000,000 New Hampshire Health & Educational Facilities Authority 864,120 1,125,000 New Hampshire Health & Educational Facilities Authority 1,081,586 1,945,706 New Jersey - 9.4% 2,500,000 Burlington County New Jersey Bridge Commission Revenue, 2,246,575 13,000,000 New Jersey Economic Development Authority Revenue, 6.25 9,639,630 2,500,000 New Jersey Health Care Facilities Financing Authority R 2,345,025 2,495,000 (a)New Jersey State Turnpike Authority, RIB, 15.746%, 1/1/ 3,389,383 1,000,000 + Tobacco Settlement Financing Corp., 6.25%, 6/1/43 1,122,680 3,250,000 + Tobacco Settlement Financing Corp., 6.75%, 6/1/39 3,721,543 5,000,000 + Tobacco Settlement Financing Corp., 7.0%, 6/1/41 5,779,000 28,243,836 New York - 9.3% 3,000,000 Dutchess County Industrial Development Agency Revenue, 3,190,590 1,000,000 Nassau County New York Industrial Development Agency Re 999,730 6,980,000 New York City Industrial Development Agency, 5.25%, 12/ 4,327,460 2,000,000 New York City Industrial Development Agency, 5.375%, 6/ 1,881,560 2,000,000 New York City Industrial Development Agency, 6.9%, 8/1/ 959,980 3,950,000 New York City Industrial Development Agency, 7.625%, 12 3,397,158 2,300,000 New York City Industrial Development Agency, 7.8%, 1/1/ 2,303,059 5,000,000 New York State Environmental Facilities Corp., 5.0%, 6/ 5,058,950 4,500,000 Suffolk County New York Industrial Development Agency, 3,525,210 500,000 Ulster County New York Industrial Development Agency, 6 445,995 2,000,000 Yonkers Industrial Development Agency Civic Facilities 1,986,520 28,076,212 North Carolina - 4.7% 11,350,000 Charlotte North Carolina Special Facilities Revenue, 5. 7,867,025 7,140,000 Charlotte North Carolina Special Facilities Revenue, 7. 6,324,255 14,191,280 Ohio - 2.2% 3,800,000 Belmont County Health System Revenue, 5.7%, 1/1/13 3,745,318 1,000,000 Belmont County Health System Revenue, 5.8%, 1/1/18 922,940 3,000,000 Cleveland Airport Special Revenue, 5.375%, 9/15/27 1,993,800 6,662,058 Oklahoma - 1.7% 1,875,000 Jackson County Memorial Hospital Authority Revenue, 7.3 1,883,663 2,220,000 Tulsa Municipal Airport Transportation Revenue, 6.25%, 1,765,233 1,500,000 Tulsa Municipal Airport Transportation Revenue, 7.35%, 1,432,560 5,081,456 Pennsylvania - 9.2% 3,000,000 + Allegheny County Hospital Development Authority Revenue 3,486,240 500,000 + Allegheny County Hospital Development Authority Revenue 581,040 1,000,000 Clarion County Hospital Authority Revenue, 5.625%, 7/1/ 1,001,800 3,600,000 Columbia County Hospital Authority Revenue, 5.85%, 6/1/ 3,099,096 3,110,000 (c)Delaware County Industrial Development Authority Revenu 2,379,865 1,050,000 Hazleton Health Services Authority Hospital Revenue, 6. 1,045,737 2,415,000 Montgomery County Higher Education & Health Authority H 2,419,733 1,430,000 Pennsylvania Economic Development Financing Authority R 1,299,799 1,805,000 Pennsylvania Economic Development Financing Authority R 1,782,311 2,330,000 Pennsylvania Economic Development Financing Authority R 2,288,643 5,000,000 Philadelphia Hospitals & Higher Education Facilities Au 4,207,450 2,005,000 Scranton-Lackawanna Health & Welfare Authority Revenue, 1,999,587 2,245,000 Scranton-Lackawanna Health & Welfare Authority Revenue, 2,237,143 27,828,444 Rhode Island - 4.1% 4,485,000 Central Falls Rhode Island Detention Facilities Revenue 4,543,754 8,285,000 Tobacco Settlement Financing Corp., 6.25%, 6/1/42 7,819,052 12,362,806 South Carolina - 6.6% 1,500,000 Connector 2000 Association, Inc., Toll Road Revenue, 5. 964,155 1,600,000 Loris Community Hospital District, 5.625%, 1/1/29 1,574,208 7,140,000 + South Carolina Jobs Economic Development Authority Reve 8,069,771 860,000 + South Carolina Jobs Economic Development Authority Reve 969,426 3,000,000 + South Carolina Jobs Economic Development Authority Reve 3,393,720 4,400,000 (d)Tobacco Settlement Revenue Management, 6.375%, 5/15/30 4,970,196 19,941,476 Tennessee - 2.8% 1,000,000 + Johnson City Health & Educational Facilities Board Hosp 1,173,890 7,000,000 Knox County Health Educational & Housing Facilities Boa 7,201,670 8,375,560 Texas - 14.6% 8,650,000 Brazos River Authority Pollution Control Revenue, 6.75% 7,138,672 4,000,000 Brazos River Authority Pollution Control Revenue, 7.7%, 3,760,200 7,350,000 Gulf Coast Industrial Development Authority, 7.0%, 12/1 6,482,773 10,000,000 Houston Texas Airport System Special Facilities Revenue 7,893,500 1,000,000 IAH Public Facility Corp., Project Revenue Bonds, Serie 940,920 1,000,000 IAH Public Facility Corp., Project Revenue Bonds, Serie 909,010 1,350,000 IAH Public Facility Corp., Project Revenue Bonds, Serie 1,202,877 845,000 Lubbock Health Facilities Development Corp., 6.5%, 7/1/ 814,665 2,000,000 Lubbock Health Facilities Development Corp., 6.625%, 7/ 1,931,020 7,750,000 Matagorda County Navigation District Number 1 Revenue, 6,985,075 5,000,000 Tomball Hospital Authority, 6.0%, 7/1/25 5,021,750 810,000 (d)Willacy County Local Government Corp., 6.0%, 3/1/09 830,039 43,910,501 Utah - 0.5% 1,600,000 Spanish Fork Charter School Revenue, 5.7%, 11/15/36 (14 1,369,920 Washington - 4.7% 5,500,000 Port Seattle Washington Special Facilities Revenue, 7.2 4,587,055 1,290,000 Tobacco Settlement Authority Revenue, 6.5%, 6/1/26 1,304,474 2,000,000 Washington State Health Care Facilities Authority, 6.12 1,899,840 2,000,000 Washington State Health Care Facilities Authority, 6.25 1,922,580 5,000,000 Washington State Housing Finance Commission Nonprofit R 4,490,900 14,204,849 Wisconsin - 1.5% 3,000,000 Aztalan Wisconsin Exempt Facilities Revenue, 7.50%, 5/1 2,532,660 1,000,000 Wisconsin State Health & Educational Facilities Authori 964,680 1,000,000 Wisconsin State Health & Educational Facilities Authori 927,740 4,425,080 TOTAL TAX-EXEMPT OBLIGATIONS (Cost $430,929,675) 422,513,756 MUNICIPAL COLLATERALIZED DEBT OBLIGATION - 4.1% of Net Assets 13,000,000(e)Non-Profit Preferred Funding Trust I, Series E, 12.0%, 12,420,850 TOTAL MUNICIPAL COLLATERALIZED DEBT OBLIGATION (Cost $13,000,000) 12,420,850 Shares COMMON STOCK - 0.2% of Net Assets 83,773 (f)Northwest Airlines Corp. 557,928 TOTAL COMMON STOCK (Cost $3,210,349) 557,928 TAX-EXEMPT MONEY MARKET MUTUAL FUND - 2.7% of Net Assets 8,000,000 BlackRock Liquidity Funds MuniFund Portfolio 8,000,000 TOTAL TAX-EXEMPT MONEY MARKET MUTUAL FUND (Cost $8,000,000) 8,000,000 TOTAL INVESTMENTS IN SECURITIES - 147.3% (Cost $455,140,024) (g)(h) 443,492,534 OTHER ASSETS AND LIABILITIES - 2.5% 7,579,975 PREFERRED SHARES AT REDEMPTION VALUE, INCLUDING DIVIDENDS PAYABLE - (49.8)% (150,006,099) NET ASSETS APPLICABLE TO COMMON SHAREOWNERS - 100.0% 301,066,410 (144A) Security is exempt from registration under Rule 144A of the Securities Act of 1933. Such securities may be resold normally to qualified institutional buyers in a transaction exempt from registration. At June 30, 2008, the value of these securities amounted to $59,381,654, or 19.7% of total net assets applicable to common shareowners. RIB Residual Interest Bonds. NR Security not rated by S&P or Moody's. + Prerefunded bonds have been collateralized by U.S. Treasury or U.S. Government Agency securities which are held in escrow to pay interest and principal on the tax exempt issue and to retire the bonds in full at the earliest refunding date. (a) The interest rate is subject to change periodically and inversely based upon prevailing market rates. The rate shown is the coupon rate at June 30, 2008. (b) Debt obligation initially issued at one coupon which converts to a higher coupon at a specific date. The rate shown is the coupon rate at June 30, 2008. (c) Security is in default and is non-income producing. (d) Escrow to maturity. (e) Indicates a security that has been deemed illiquid. The aggregate cost of illiquid securities is $13,000,000. The aggregate value is $12,420,850, or 4.1% of the net assets. (f) Non-income producing. (g) The concentration of investments by type of obligation/market sector is as follows: Insured FSA 5.7% ACA 1.4 AMBAC 0.6 General Obligation 5.5 Revenue Bonds: Health Revenue 27.2 Development Revenue 11.1 Tobacco Revenue 9.7 Airport Revenue 8.7 Facilities Revenue 7.0 Pollution Control Revenue 6.1 Other Revenue 5.6 Transportation Revenue 4.4 Utilities Revenue 2.6 Housing Revenue 1.7 Education Revenue 1.3 Water Revenue 1.1 Power Revenue 0.3 100.0% (h) At June 30, 2008, the net unrealized loss on investments based on cost for federal income tax purposes of $451,177,623 was as follows: Aggregate gross unrealized gain for all investments in which there is an excess of value over tax cost $19,478,863 Aggregate gross unrealized loss for all investments in which there is an excess of tax cost over value (27,163,952) Net unrealized gain $(7,685,089) For financial reporting purposes net unrealized loss on investments was $11,647,490 and cost of investments aggregated $455,140,024. FAS 157 Footnote Disclosures Various inputs are used in determining the value of the Fund's investments. These inputs are summarized in the three broad levels listed below. Highest priority is given to Level 1 inputs and lowest priority is given to Level 3. Level 1 - quoted prices in active markets for identical securities Level 2 - other significant observable inputs (including quoted prices for similar securities, interest rates, prepayment speeds, credit risk, etc.) Level 3 - significant unobservable inputs (including the Fund's own assumptions in determining fair value of investments) The following is a summary of the inputs used as of June 30, 2008, in valuing the Fund's assets: Investments Other Financial Valuation Inputs in Securities Instruments Level 1 - Quoted Prices 557,928 0 Level 2 - Other Significant Observable Inputs 442,934,606 (329,607) Level 3 - Significant Unobservable Inputs 0 0 Total 443,492,534 (329,607) ITEM 2. CONTROLS AND PROCEDURES. (a)Disclose the conclusions of the registrant's principal executive officer or officers and principal financial officer or officers, or persons performing similar functions, about the effectiveness of the registrant's disclosure controls and procedures (as defined in Rule 30a-3(c) under the Act (17 CFR 270.30a-3(c))) as of a date within 90 days of the filing date of the report that includes the disclosure required by this paragraph, based on their evaluation of these controls and procedures required by Rule 30a-3(b) under the Act (17 CFR270.30a-3(b))) and Rule 13a-15(b) or 15d-15(b) under the Exchange Act (17 CFR240.13a-15(b) or 240.15d-15(b)). The registrant's principal executive officer and principal financial officer have concluded that the registrant's disclosure controls and procedures are effective based on their evaluation of these controls and procedures as of a date within 90 days of the filing date of this report. (b) Disclose any change in the registrant's internal controls over financial reporting (as defined in Rule 30a-3(d) under the Act (17 CFR270.30a-3(d)) that occurred during the registrant's last fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting. There were no significant changes in the registrant's internal control over financial reporting that occurred during the second fiscal quarter of the period covered by this report that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting. ITEM 3. EXHIBITS. (a) A separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2 under the Act (17 CFR 270.30a-2). Filed herewith. SIGNATURES [See General Instruction F] Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. (Registrant) Pioneer Municipal High Income Advantage Trust By (Signature and Title)* /s/ John F. Cogan, Jr. John F. Cogan, Jr, President Date August 29, 2008 Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated. By (Signature and Title)* /s/ John F. Cogan, Jr. John F. Cogan, Jr., President Date August 29, 2008 By (Signature and Title)* /s/ Mark Bradley Mark Bradley, Treasurer Date August 29, 2008 * Print the name and title of each signing officer under his or her signature.