SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

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                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

       Date of report (Date of earliest event reported): November 6, 2003
                                                         ----------------

                               CYTOGEN CORPORATION
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               (Exact Name of Registrant as Specified in Charter)

          Delaware                       000-14879                222322400
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(State or Other Jurisdiction     (Commission File Number)     (I.R.S. Employer
      of Incorporation)                                      Identification No.)

650 College Road East, CN 5308, Suite 3100, Princeton, NJ               08540
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      (Address of Principal Executive Offices)                        (Zip Code)

       Registrant's telephone number, including area code: (609) 750-8200
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ITEM 5.    OTHER EVENTS.

         On October 29, 2003, Cytogen  Corporation,  a Delaware corporation (the
"Company")   filed  a  registration   statement  (File  No.   333-110040)   (the
"Registration   Statement")  on  Form  S-3  with  the  Securities  and  Exchange
Commission (the  "Commission")  relating to the public offering pursuant to Rule
415 under the  Securities  Act of 1933,  as amended,  of up to an  aggregate  of
$60,000,000 in shares of common stock of the Company.  The  Commission  declared
the Registration Statement effective on October 30, 2003.

         On  November  6,  2003,  the  Company  entered  into a  Share  Purchase
Agreement (the "Share Purchase Agreement") with certain institutional  investors
pursuant to which the Company  issued and sold an aggregate of 1,863,637  shares
of its common  stock at a purchase price of $11.00 per share for aggregate gross
proceeds of $20.5 million.

         A copy of each of the Share  Purchase  Agreement  and the related press
release of the Company,  dated  November 7, 2003, are filed herewith as Exhibits
10.1 and 99.1,  respectively,  and are  incorporated  herein by  reference.  The
foregoing  description  of the  issuance  of  Common  Stock  by the  Company  is
qualified in its entirety by reference to such Exhibits.

ITEM 7.    FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

      (c)    Exhibits.

               Exhibit No.     Description
               -----------     -----------
                  10.1         Share Purchase Agreement by and among the Company
                               and the Purchasers dated November 6, 2003.

                  99.1         Press release of the Company dated November 7,
                               2003.






                                   SIGNATURES



         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                  CYTOGEN CORPORATION


                                  By:  /s/ Michael D. Becker
                                       -------------------------------------
                                       Michael D. Becker
                                       President and Chief Executive Officer


Dated:   November 7, 2003






                                  EXHIBIT INDEX


        Exhibit No.      Description
        -----------      -----------

           10.1          Share Purchase  Agreement by and among the Company and
                         the Purchasers dated November 6, 2003.

           99.1          Press release of the Company dated November 7, 2003.