FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person *   Quimi Daphne 2. Date of Event Requiring Statement (Month/Day/Year) 02/03/2011 3. Issuer Name and Ticker or Trading Symbol AMICUS THERAPEUTICS INC [FOLD] (Last) (First) (Middle) C/O AMICUS THERAPEUTICS 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) Corporate Controller 5. If Amendment, Date Original Filed(Month/Day/Year) (Street) CRANBURY, NJ 08512 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Options (right to buy)	  (1)	09/04/2017	Common Stock	10,000	$ 16.57	D	Â
Stock Options (right to buy)	  (2)	02/05/2018	Common Stock	7,000	$ 10.21	D	Â
Stock Options (right to buy)	  (3)	02/03/2019	Common Stock	8,000	$ 10.36	D	Â
Stock Options (right to buy)	  (4)	11/16/2019	Common Stock	15,000	$ 4.16	D	Â
Stock Optons (right to buy)	  (5)	06/15/2020	Common Stock	6,000	$ 2.81	D	Â
Stock Options (right to buy)	  (6)	01/19/2021	Common Stock	8,750	$ 5.96	D	Â
Stock Options (right to buy)	  (6)(7)	06/16/2021	Common Stock	15,000	$ 6.06	D	Â
Stock Options (right to buy)	  (6)(8)	02/15/2022	Common Stock	8,750	$ 6.45	D	Â

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Quimi Daphne C/O AMICUS THERAPEUTICS CRANBURY, NJ 08512	Â	Â	  Corporate Controller	Â

Signatures

/s/ Daphne Quimi		02/23/2012
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	These options vested and became exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on September 4, 2008. The remaining options vested and became exercisable in a series of thirty-five equal monthly installments, beginning on October 1, 2008, with a final installment vesting on September 4, 2011.
(2)	These options vested and became exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on February 5, 2009. The remaining options vested and became exercisable in a series of thirty-five equal monthly installments, beginning on March 1, 2009, with a final installment vesting on February 5, 2012.
(3)	These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on February 3, 2010. The remaining options vest and become exercisable in a series of thirty-five equal monthly installments, beginning on March 1, 2010, with a final installment vesting on February 3, 2013.
(4)	These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on November 16, 2010. The remaining options vest and become exercisable in a series of thirty-five equal monthly installments, beginning on December 1, 2010, with a final installment vesting on November 16, 2013.
(5)	These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on June 15, 2011. The remaining options vest and become exercisable in a series of thirty-five equal monthly installments, beginning on July 1, 2011, with a final installment vesting on June 15, 2014.
(6)	These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on January 19, 2012. The remaining options vest and become exercisable in a series of thirty-five equal monthly installments, beginning on February 1, 2013, with a final installment vesting on January 19, 2015.
(7)	These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vests on June 16, 2012. The remaining options vest and become exercisable in a series of thirty-five equal monthly installments, beginning on July 1, 2012, with a final installment vesting on June 16, 2015.
(8)	These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vests on February 15, 2013. The remaining options vest and become exercisable in a series of thirty-five equal monthly installments, beginning on March 1, 2013, with a final installment vesting on February 15, 2016.

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