FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * CLINGEN BRIAN T   2. Issuer Name and Ticker or Trading Symbol ENDO PHARMACEUTICALS HOLDINGS INC [ENDP] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner _____ Officer (give title below) __X__ Other (specify below) Director until 3/15/2006 (Last) (First) (Middle) 5101 DARMSTADT ROAD, SUITE A 3. Date of Earliest Transaction (Month/Day/Year) 03/27/2006 (Street) HILLSIDE, IL 60162 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock, par value $.01 per share 03/27/2006   M   1,250 A $ 11.05 1,250 (1) D   Common Stock, par value $.01 per share 03/27/2006   M   2,500 A $ 20.42 5,000 (2) D   Common Stock, par value $.01 per share 03/27/2006   S   3,750 D $ 31.65 16,250 (3) D

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Stock options granted pursuant to 2000 Stock Incentive Plan

$ 11.05

03/27/2006

M

1,250

(4)

03/12/2013

Common Stock

1,250

$ 0

1,250 (1)

D

Stock options granted pursuant to 2000 Stock Incentive Plan

$ 20.42

03/27/2006

M

2,500

(5)

03/12/2014

Common Stock

2,500

$ 0

5,000 (2)

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
CLINGEN BRIAN T 5101 DARMSTADT ROAD SUITE A HILLSIDE, IL 60162				Director until 3/15/2006

Signatures

/s/ Caroline B. Manogue, by power of attorney		03/29/2006
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	This number represents options to purchase 1,250 shares of our common stock granted under the Endo Pharmaceuticals Holdings Inc. 2000 Stock Incentive Plan, none of which are currently exercisable and all of which expire on June 13, 2006 due to Mr. Clingen's resignation from the Endo Board of Directors effective March 15, 2006.
(2)	This number represents options to purchase 5,000 shares of our common stock granted under the Endo Pharmaceuticals Holdings Inc. 2000 Stock Incentive Plan, none of which are currently exercisable and all of which expire on June 13, 2006 due to Mr. Clingen's resignation from the Endo Board of Directors effective March 15, 2006.
(3)	Mr. Clingen's amount of securities beneficially owned following the reported transactions represents options to purchase 16,250 shares of our common stock granted under the Endo Pharmaceuticals Holdings Inc. 2000 and 2004 Stock Incentive Plans, 2,500 of which are currently exercisable and all of which expire on June 13, 2006 due to Mr. Clingen's resignation from the Endo Board of Directors effective March 15, 2006.
(4)	These 1,250 options became exercisable on 3/12/06.
(5)	These 2,500 options became exercisable on 3/12/06.

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