Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
MILLIGAN JOHN F
  2. Issuer Name and Ticker or Trading Symbol
GILEAD SCIENCES INC [GILD]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
COO and CFO
(Last)
(First)
(Middle)
333 LAKESIDE DRIVE
3. Date of Earliest Transaction (Month/Day/Year)
09/04/2007
(Street)

FOSTER CITY, CA 94404
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 09/04/2007   M   53,280 (1) A $ 4.905 260,673 (2) D  
Common Stock 09/04/2007   M   6,720 (1) A $ 8.5813 267,393 (2) D  
Common Stock 09/04/2007   S   5,000 (1) D $ 36.4633 262,393 (2) D  
Common Stock 09/04/2007   S   5,000 (1) D $ 36.54 257,393 (2) D  
Common Stock 09/04/2007   S   10,000 (1) D $ 36.585 247,393 (2) D  
Common Stock 09/04/2007   S   10,000 (1) D $ 36.649 237,393 (2) D  
Common Stock 09/04/2007   S   10,000 (1) D $ 36.79 227,393 (2) D  
Common Stock 09/04/2007   S   4,644 (1) D $ 36.9313 222,749 (2) D  
Common Stock 09/04/2007   S   15,356 (1) D $ 36.9113 207,393 (2) (3) D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (right to buy) $ 4.905 09/04/2007   M     53,280   (4) 04/17/2011 Common Stock 53,280 $ 0 0 D  
Non-Qualified Stock Option (right to buy) $ 8.5813 09/04/2007   M     6,720   (5) 10/24/2011 Common Sto 6,720 $ 0 153,280 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
MILLIGAN JOHN F
333 LAKESIDE DRIVE
FOSTER CITY, CA 94404
      COO and CFO  

Signatures

 /s/ John F. Milligan   09/04/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The exercise and sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan established by John Milligan on May 16, 2007.
(2) All shares and dollar amounts reflect a two-for-one split that was effected on June 22, 2007 benefiting all shareholders of record as of May 24, 2007.
(3) Amount of securities beneficially owned following the reported transactions includes 791 shares acquired under the Gilead Sciences, Inc. Employee Stock Purchase Plan on June 29, 2007.
(4) The options vested 20% on April 18, 2002, the first anniversary date of the grant. The balance vested 5% every three months thereafter and was fully vested as of April 18, 2006.
(5) The options vested 20% on October 25, 2002, the first anniversary date of the grant. The balance vested 5% every three months thereafter and was fully vested as of October 25, 2006.

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