OMB APPROVAL OMB Number: 3235-0578 Expires: May 31, 2007 Estimated average burden hours per response..... 21.09 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM N-Q CERTIFIED SHAREHOLDER REPORT OF REGISTERED MANAGEMENT INVESTMENT COMPANIES Investment Company Act file number 811-21409 Pioneer Municipal High Income Advantage Trust (Exact name of registrant as specified in charter) 60 State Street, Boston, MA 02109 (Address of principal executive offices) (ZIP code) Dorothy E. Bourassa, Pioneer Investment Management, Inc., 60 State Street, Boston, MA 02109 (Name and address of agent for service) Registrant's telephone number, including area code: (617) 742-7825 Date of fiscal year end: March 31 Date of reporting period: June 30, 2006 Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after close of the first and third fiscal quarters, pursuant to Rule 30b1-5under the Investment Company Act of 1940 (17 CFR 270.30b-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles. A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget ("OMB") control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. ss. 3507. ITEM 1. Schedule of Investments. Pioneer Municipal High Income Advantage Trust SCHEDULE OF INVESTMENTS 6/30/06 (unaudited) Principal Amount ($) Value TAX-EXEMPT OBLIGATIONS - 141.7% of Net Assets Alaska - 1.2% 3,875,000(aAlaska State Housing Finance Corp., RIB, 10.069%, $ 4,370,884 Arizona - 5.6% 5,000,000 Casa Grande Industrial Development Authority, Hos $ 5,489,750 3,130,000 Coconino County Arizona Pollution Control Corp. R 3,074,411 1,615,000 Coconino County Arizona Pollution Control Corp. R 1,638,660 3,140,000(aDowntown Phoenix Hotel Corp., RIB, 6.806%, 7/1/40 3,169,202 1,000,000 Pima County Industrial Development Authority, 6.3 1,023,820 1,570,000 Pima County Industrial Development Authority, 6.7 1,628,467 1,000,000 +Pima County Industrial Development Authority, 7.5 1,196,770 2,000,000 San Luis Facility Development Corp., 7.25%, 5/1/2 2,004,620 $ 19,225,700 California - 6.6% 2,680,000 Golden State Tobacco Securitization Corp., 6.75%, $ 2,999,536 9,520,000(aUniversity of California, RIB, 6.972%, 5/15/38 (1 10,045,694 9,455,000 Valley Health System Hospital Revenue, 6.875%, 5 9,466,724 $ 22,511,954 Colorado - 1.8% 2,850,000 Denver Health & Hospital Authority Healthcare Rev $ 2,973,946 3,650,000 Northwest Parkway Public Highway Authority, 7.125 3,378,951 $ 6,352,897 Connecticut - 0.7% 3,000,000 Bridgeport Connecticut Senior Living Facilities R $ 2,516,790 District of Columbia - 2.1% 2,700,000 District of Columbia Tobacco Settlement Financing $ 3,035,340 4,000,000 District of Columbia Tobacco Settlement Financing 4,339,720 $ 7,375,060 Florida - 5.8% 1,000,000 Greater Orlando Aviation Authority, 6.5%, 11/15/3 $ 1,039,670 4,500,000 Hillsborough County Florida Industrial Development Authority Pollution Control Revenue, 5.5%, 10/1/23 4,603,185 2,000,000 Hillsborough County Florida Industrial Development Authority Pollution Control Revenue, 6.75%, 7/1/29 2,025,740 500,000 Miami Beach Health Facilities Authority, 5.375%, 493,245 1,500,000 Miami Beach Health Facilities Authority, 6.7%, 11 1,633,905 10,000,000 Miami-Dade County Aviation Revenue, 5.0%, 10/1/37 10,101,000 $ 19,896,745 Georgia - 2.7% 4,000,000(aAtlanta Georgia Water and Wastewater Revenue, RIB $ 4,088,040 2,500,000 Brunswick & Glynn County Development Authority Re 2,449,525 1,065,000 Effingham County Industrial Development Authority 1,117,473 1,650,000 Savannah Georgia Economic Development Authority R 1,712,964 $ 9,368,002 Guam - 1.6% 5,000,000 Northern Mariana Islands, 6.75%, 10/1/33 $ 5,531,750 Idaho - 2.4% 2,000,000 Power County Industrial Development Corp., 6.45%, $ 2,126,880 5,920,000 Power County Pollution Control Revenue, 5.625% 10 6,032,835 $ 8,159,715 Illinois - 4.3% 4,000,000 Centerpoint Intermodal Center, 8.0%, 6/15/23 (144 $ 4,013,400 1,000,000 Illinois Finance Authority Revenue, 6.0%, 11/15/2 1,002,210 3,000,000 Illinois Finance Authority Revenue, 6.0%, 11/15/3 2,972,400 1,645,000 Illinois Health Facilities Authority Revenue, 5.5 1,515,094 1,400,000 Illinois Health Facilities Authority Revenue, 6.7 1,399,944 2,400,000 Illinois Health Facilities Authority Revenue, 6.7 2,370,480 1,500,000 Illinois Health Facilities Authority Revenue, 6.9 1,627,290 $ 14,900,818 Indiana - 5.5% 1,200,000 Indiana State Development Finance Authority Pollu $ 1,226,652 10,000,000 Indiana State Development Finance Authority Reven 10,297,700 5,000,000 Jasper County Industrial Economic Development Rev 4,923,700 2,315,000 Vincennes Industrial Economic Development Revenue 2,301,365 $ 18,749,417 Kentucky - 1.4% 500,000 Kentucky Economic Development Finance Authority H $ 506,240 4,400,000 Kentucky Economic Development Finance Authority H 4,431,152 $ 4,937,392 Louisiana - 3.1% 750,000 Opelousas Louisiana General Hospital Authority Re $ 750,555 9,415,000 Tobacco Settlement Financing Corp., 5.875%, 5/15/ 9,847,808 $ 10,598,363 Maryland - 0.4% 1,500,000 Maryland Health & Higher Educational Facilities A $ 1,509,210 Massachusetts - 7.6% 1,000,000 Lynn Massachusetts Water & Sewer Commission Gener $ 1,014,820 5,000,000 Massachusetts Bay Transportation Authority Revenu 5,219,250 2,195,000 Massachusetts Health & Educational Facilities Aut 2,127,460 1,000,000 Massachusetts Health & Educational Facilities Aut 1,042,410 3,520,000(aMassachusetts State College Building Authority Pr 3,656,330 1,740,000 Massachusetts State Development Finance Agency, 5 1,599,391 2,920,000 Massachusetts State Development Finance Agency, 6 2,947,390 4,710,000 Massachusetts State Development Finance Agency, 7 4,874,238 3,475,000(aMassachusetts State Housing Finance Agency, RIB, 3,475,730 $ 25,957,019 Michigan - 4.4% 3,000,000 +Delta County Michigan Economic Development Corp., $ 3,340,410 3,000,000 Macomb County Hospital Finance Authority Revenue, 3,152,520 4,130,000 Michigan State Hospital Finance Authority Revenue 3,948,858 1,000,000 Michigan State Strategic Fund Solid Waste Disposa 1,026,450 3,000,000(bWayne Charter County Michigan Special Airport Fac 1,653,330 3,405,000(bWayne Charter County Michigan Special Airport Fac 1,895,325 $ 15,016,893 Minnesota - 1.0% 4,800,000(bMinneapolis/St. Paul Metropolitan Airports, 7.0%, $ 3,368,256 Missouri - 1.0% 1,500,000 St. Louis Industrial Development Authority Revenu $ 1,445,280 2,000,000 St. Louis Industrial Development Authority Revenu 1,927,340 $ 3,372,620 Montana - 0.3% 1,000,000 Two Rivers Authority, Inc., Project Revenue, 7.37 $ 965,860 Nevada - 2.4% 2,425,000 Clark County Industrial Development Revenue, 5.5% $ 2,366,727 2,500,000 Clark County Industrial Development Revenue, 5.9% 2,500,350 1,600,000 Nevada State Department of Business & Industry, 7 1,659,104 1,000,000 Nevada State Department of Business & Industry, 7 1,040,640 500,000 Nevada State Department of Business & Industry, 7 518,265 $ 8,085,086 New Hampshire - 1.5% 1,000,000 New Hampshire Health & Educational Facilities Aut $ 1,020,510 1,125,000 New Hampshire Health & Educational Facilities Aut 1,143,067 3,000,000 +New Hampshire Higher Educational & Health Facilit 3,145,020 $ 5,308,597 New Jersey - 9.0% 13,000,000 New Jersey Economic Development Authority Revenue $ 13,298,220 2,500,000 New Jersey Health Care Facilities Financing Autho 2,537,850 1,420,000 New Jersey Health Care Facilities Financing Autho 1,421,789 2,495,000(aNew Jersey State Turnpike Authority, RIB, 8.581%, 3,385,840 1,000,000 Tobacco Settlement Financing Corp., 6.25%, 6/1/43 1,078,370 3,250,000 Tobacco Settlement Financing Corp., 6.75%, 6/1/39 3,627,325 5,000,000 Tobacco Settlement Financing Corp., 7.0%, 6/1/41 5,669,200 $ 31,018,594 New York - 11.0% 3,000,000 Dutchess County Industrial Development Agency Rev $ 3,244,650 5,000,000 Nassau County New York Industrial Development Age 5,063,400 6,980,000 New York City Industrial Development Agency, 5.25 6,570,623 2,000,000 New York City Industrial Development Agency, 5.37 2,044,620 2,000,000 New York City Industrial Development Agency, 6.9% 2,000,640 3,950,000 New York City Industrial Development Agency, 7.62 4,438,971 2,700,000 New York City Industrial Development Agency, 7.8% 2,764,422 5,000,000 New York State Environmental Facilities Corp., 5. 5,091,000 4,500,000 Suffolk County New York Industrial Development Ag 4,458,420 2,000,000 Yonkers Industrial Development Agency Civic Facil 1,981,880 $ 37,658,626 North Carolina - 5.5% 11,350,000 Charlotte North Carolina Special Facilities Reven $ 11,137,074 7,140,000 Charlotte North Carolina Special Facilities Reven 7,642,585 $ 18,779,659 Ohio - 2.7% 3,900,000 Belmont County Health System Revenue, 5.7%, 1/1/1 $ 3,786,783 1,000,000 Belmont County Health System Revenue, 5.8%, 1/1/1 950,890 5,000,000 Cleveland Airport Special Revenue, 5.375%, 9/15/2 4,576,950 $ 9,314,623 Oklahoma - 1.1% 2,345,000 Jackson County Memorial Hospital Authority Revenu $ 2,357,171 1,500,000 Tulsa Municipal Airport Transportation Revenue, 7 1,499,745 $ 3,856,916 Oregon - 4.2% 5,900,000 Klamath Falls Electric Revenue, 5.75%, 1/1/13 (14 $ 5,252,062 8,000,000 Klamath Falls Electric Revenue, 6.0%, 1/1/25 (144 6,510,080 2,500,000 Western Generation Agency Cogeneration Project Re 2,508,425 $ 14,270,567 Pennsylvania - 6.7% 3,000,000 Allegheny County Hospital Development Authority R $ 3,551,070 500,000 Allegheny County Hospital Development Authority R 590,805 1,000,000 Clarion County Hospital Authority Revenue, 5.625% 1,004,240 3,735,000 Columbia County Hospital Authority Revenue, 5.85% 3,341,966 1,250,000 Hazleton Health Services Authority Hospital Reven 1,229,400 3,360,000 Montgomery County Higher Education & Health Autho 3,429,888 1,430,000 Pennsylvania Economic Development Financing Autho 1,370,240 1,805,000 Pennsylvania Economic Development Financing Autho 1,799,874 2,330,000 Pennsylvania Economic Development Financing Autho 2,323,919 2,005,000 Scranton-Lackawanna Health & Welfare Authority Re 1,993,090 2,245,000 Scranton-Lackawanna Health & Welfare Authority Re 2,231,687 $ 22,866,179 Rhode Island - 4.0% 4,485,000 Central Falls Rhode Island Detention Facilities R $ 4,919,372 8,285,000 Tobacco Settlement Financing Corp., 6.25%, 6/1/42 8,680,029 $ 13,599,401 South Carolina - 5.8% 1,500,000 Connector 2000 Association, Inc., Toll Road Reven $ 1,310,970 1,600,000 Loris Community Hospital District, 5.625%, 1/1/29 1,623,776 7,140,000 +South Carolina Jobs Economic Development Authorit 8,090,905 860,000 South Carolina Jobs Economic Development Authorit 949,191 3,000,000 South Carolina Jobs Economic Development Authorit 3,262,620 4,400,000 Tobacco Settlement Revenue Management, 6.375%, 5/ 4,845,676 $ 20,083,138 Tennessee - 2.5% 1,000,000 Johnson City Health & Educational Facilities Boar $ 1,148,320 7,000,000 Knox County Health Educational & Housing Faciliti 7,363,230 $ 8,511,550 Texas - 18.2% 11,300,000 Alliance Airport Authority Special Facilities Rev $ 11,297,966 8,650,000 Brazos River Authority Pollution Control Revenue, 9,664,039 13,885,000 Dallas-Fort Worth International Airport Revenue, 13,477,614 10,000,000 Houston Texas Airport System Revenue, 6.75%, 7/1/ 10,629,100 845,000 Lubbock Health Facilities Development Corp., 6.5% 856,255 2,000,000 Lubbock Health Facilities Development Corp., 6.62 2,024,760 7,750,000 Matagorda County Navigation District Number 1 Rev 7,966,147 1,885,000 Panhandle Texas Regional Housing Finance, 8.125%, 1,593,428 5,000,000 Tomball Hospital Authority, 6.0%, 7/1/25 5,143,600 $ 62,652,909 Virginia - 0.5% 1,555,000 +Pocahontas Parkway Association of Virginia Toll R $ 1,623,871 Washington - 6.5% 10,000,000 Port Seattle Washington Special Facilities Revenu $ 10,058,900 5,500,000(bPort Seattle Washington Special Facilities Revenu 3,469,785 1,390,000 Tobacco Settlement Authority Revenue, 6.5%, 6/1/2 1,510,624 6,960,000(aWashington State Economic Development Finance Aut 7,129,198 $ 22,168,507 Wisconsin - 0.6% 1,000,000 Wisconsin State Health & Educational Facilities A $ 1,015,590 1,000,000 Wisconsin State Health & Educational Facilities A 1,009,840 $ 2,025,430 TOTAL TAX-EXEMPT OBLIGATIONS (Cost $450,612,780) $ 486,508,998 Shares TAX-EXEMPT MONEY MARKET MUTUAL FUND - 0.0% of Net Assets 838 BlackRock Provident Institutional Municipal Fund $ 838 TOTAL TAX-EXEMPT MONEY MARKET MUTUAL FUND (Cost $838) $ 838 TOTAL INVESTMENTS IN SECURITIES - 141.7% (Cost $450,613,618) (c)(d) $ 486,509,836 OTHER ASSETS AND LIABILITIES - 2.0% $ 6,979,473 PREFERRED SHARES AT REDEMPTION VALUE, INCLUDING DIVIDENDS PAYABLE - (43.7)% $ (150,069,964) NET ASSETS APPLICABLE TO COMMON SHAREOWNERS - 100 $ 343,419,345 (144A) Security is exempt from registration under Rule 144A of the Securities Act of 1933. Such securities may be resold normally to qualified institutional buyers in a transaction exempt from registration. At June 30, 2006, the value of these securities amounted to $59,068,020, or 17.2% of total net assets applicable to common shareowners. RIB Residual Interest Bonds. NR Security not rated by S&P or Moody's. + Prerefunded bonds have been collateralized by U.S. Treasury securities which are held in escrow to pay interest and principal on the tax exempt issue and to retire the bonds in full at the earliest refunding date. (a) The interest rate is subject to change periodically and inversely based upon prevailing market rates. The interest rate shown was the rate at June 30, 2006. (b) Security is in default and is non-income producing. (c) The concentration of investments by type of obligation/market sector is as follows: Insured 12.4% General Obligation 1.1 Revenue Bonds: Health Revenue 24.8 Airport Revenue 16.5 Development Revenue 9.0 Tobacco Revenue 9.4 Pollution Control Revenue 7.0 Transportation Revenue 6.8 Facilities Revenue 5.7 Power Revenue 2.9 Education Revenue 1.2 Water Revenue 1.1 Housing Revenue 1.1 Utilities Revenue 0.8 Other 0.2 100.0% (d) At June 30, 2006, the net unrealized gain on investments based on cost for federal income tax purposes of $447,959,186 was as follows: Aggregate gross unrealized gain for all investments in which there is an excess of value over tax cost 50,307,358 Aggregate gross unrealized loss for all investments in which there is an excess of tax cost over value (11,756,708) Net unrealized gain 38,550,650 For financial reporting purposes net unrealized gain on investments was $35,896,218 and cost of investments aggregated $450,613,618. ITEM 2. CONTROLS AND PROCEDURES. (a) Disclose the conclusions of the registrant's principal executive officer or officers and principal financial officer or officers, or persons performing similar functions, about the effectiveness of the registrant's disclosure controls and procedures (as defined in Rule 30a-3(c) under the Act (17 CFR 270.30a-3(c))) as of a date within 90 days of the filing date of the report that includes the disclosure required by this paragraph, based on their evaluation of these controls and procedures required by Rule 30a-3(b) under the Act (17 CFR270.30a-3(b))) and Rule 13a-15(b) or 15d-15(b) under the Exchange Act (17 CFR240.13a-15(b) or 240.15d-15(b)). The registrant's principal executive officer and principal financial officer have concluded that the registrant's disclosure controls and procedures are effective based on their evaluation of these controls and procedures as of a date within 90 days of the filing date of this report. (b) Disclose any change in the registrant's internal controls over financial reporting (as defined in Rule 30a-3(d) under the Act (17 CFR270.30a-3(d)) that occurred during the registrant's last fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting. There were no significant changes in the registrant's internal control over financial reporting that occurred during the second fiscal quarter of the period covered by this report that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting. The registrant's principal executive officer and principal financial officer, however, voluntarily are reporting the following information: In August of 2006 the registrant's investment adviser enhanced its internal procedures for reporting performance information required to be included in prospectuses. Those enhancements involved additional internal controls over the appropriateness of performance data generated for this purpose. Such enhancements were made following an internal review which identified prospectuses relating to certain classes of shares of a limited number of registrants where, inadvertently, performance information not reflecting the deduction of applicable sales charges was included. Those prospectuses were revised, and the revised prospectuses were distributed to shareholders. ITEM 3. EXHIBITS. (a) A separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2 under the Act (17 CFR 270.30a-2). Filed herewith. SIGNATURES [See General Instruction F] Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. (Registrant) Pioneer Municipal High Income Advantage Trust By (Signature and Title)* /s/ John F. Cogan, Jr. John F. Cogan, Jr, President Date August 30, 2006 Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated. By (Signature and Title)* /s/ John F. Cogan, Jr. John F. Cogan, Jr., President Date August 30, 2006 By (Signature and Title)* /s/ Vincent Nave Vincent Nave, Treasurer Date August 30, 2006 * Print the name and title of each signing officer under his or her signature.