FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person *   OXFORD BIOSCIENCE PARTNERS IV LP 2. Date of Event Requiring Statement (Month/Day/Year) 03/04/2005 3. Issuer Name and Ticker or Trading Symbol Solexa, Inc. [SLXA] (Last) (First) (Middle) 222 BERKELEY ST. 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) 5. If Amendment, Date Original Filed(Month/Day/Year) (Street) BOSTON, MA 02116 6. Individual or Joint/Group Filing(Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common 2,468,986 D (1)   Common 24,771 I By mRNA Fund II L.P. (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
OXFORD BIOSCIENCE PARTNERS IV LP 222 BERKELEY ST. BOSTON, MA 02116	Â	  X	Â	Â
MRNA FUND II LP 222 BERKELEY ST. BOSTON, MA 02116	Â	  X	Â	Â
OBP MANAGEMENT IV LP 222 BERKELEY ST. BOSTON, MA 02116	Â	  X	Â	Â
BARNES JEFFREY T 222 BERKELEY ST. BOSTON, MA 02116	Â	  X	Â	Â
CARTHY MARK 222 BERKELEY ST. BOSTON, MA 02116	  X	  X	Â	Â
FLEMING JONATHAN 222 BERKELEY ST. BOSTON, MA 02116	Â	  X	Â	Â
LYTTON MICHAEL 222 BERKELEY ST. BOSTON, MA 02116	Â	  X	Â	Â
WALTON ALAN G 222 BERKELEY ST. BOSTON, MA 02116	Â	  X	Â	Â

Signatures

/s/ Jonathan J. Fleming, as general partner of the general partner of Oxford Bioscience Partners IV L.P.		03/14/2005
**Signature of Reporting Person		Date
/s/ Jonathan J. Fleming, as general partner of the general partner of mRNA Fund II L.P.		03/14/2005
**Signature of Reporting Person		Date
/s/ Jonathan J. Fleming, as general partner of OBP Management IV L.P.		03/14/2005
**Signature of Reporting Person		Date
/s/ Raymond Charest, as attorney-in-fact for Jeffrey T. Barnes		03/14/2005
**Signature of Reporting Person		Date
/s/ Mark P. Carthy		03/14/2005
**Signature of Reporting Person		Date
/s/ Jonathan J. Fleming		03/14/2005
**Signature of Reporting Person		Date
/s/ Michael E. Lytton		03/14/2005
**Signature of Reporting Person		Date
/s/ Alan G. Walton		03/14/2005
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Securities held of record by Oxford Bioscience Partners IV L.P. ("Oxford IV"). By virtue of their relationship as affiliated limited partnerships, whose sole general partner shares individual general partners, Oxford IV and mRNA Fund II L.P. ("mRNA") may be deemed to share voting power and the power to direct the disposition of the shares which each partnership owns of record. OBP Management IV L.P. ("OBP IV") (as the general partner of Oxford IV and mRNA II), may also be deemed to own beneficially the shares held of record by Oxford IV and mRNA II. Each of Messrs. Barnes, Carthy (who is a Director of the issuer), Fleming, Lytton, and Walton, the individual general partners of OBP IV, may be deemed to own beneficially the shares held by Oxford IV and mRNA II.
(2)	Securities held of record by mRNA. By virtue of their relationship as affiliated limited partnerships, whose sole general partner shares individual general partners, Oxford IV and mRNA may be deemed to share voting power and the power to direct the disposition of the shares which each partnership owns of record. OBP IV (as the general partner of Oxford IV and mRNA II), may also be deemed to own beneficially the shares held of record by Oxford IV and mRNA II. Each of Messrs. Barnes, Carthy (who is a Director of the issuer), Fleming, Lytton, and Walton, the individual general partners of OBP IV, may be deemed to own beneficially the shares held by Oxford IV and mRNA II.

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