SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                                (RULE 13d - 102)

    INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b),
            (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d

                               (Amendment No. 1)*

Inverness Medical Innovations, Inc.                
----------------------------------
(Name of Issuer)

          Common Stock                                
----------------------------------
(Title of Class of Securities)

           46126P106                                           
----------------------------------
(CUSIP Number)

         December 31, 2005                  
----------------------------------
(Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ]      Rule 13d-1(b)
[x]      Rule 13d-1(c)
[ ]      Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                       (Continued on the Following Pages)


1.   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

                  Amaranth LLC

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a) [x] 
         (b) [ ]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

         Cayman Islands

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5.   SOLE VOTING POWER

            0

6.   SHARED VOTING POWER

          932,800                            

7.   SOLE DISPOSITIVE POWER

            0

8.   SHARED DISPOSITIVE POWER

           932,800                            

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           See 6 and 8 above.

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
     EXCLUDES CERTAIN SHARES*    [   ]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           3.4%                               

12.  TYPE OF REPORTING PERSON*

           CO





1.   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

       Amaranth Global Equities Master Fund Limited

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a) [x] 
         (b) [ ]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

         Cayman Islands

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5.   SOLE VOTING POWER

           0

6.   SHARED VOTING POWER

         932,800                            

7.   SOLE DISPOSITIVE POWER

           0

8.   SHARED DISPOSITIVE POWER

         932,800                            

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         See 6 and 8 above.

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
     EXCLUDES CERTAIN SHARES*    [   ]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         3.4%                               

12.  TYPE OF REPORTING PERSON*

         CO



1.   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Amaranth Advisors L.L.C.

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

         (a) [x] 
         (b) [ ]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5.   SOLE VOTING POWER

           0

6.   SHARED VOTING POWER

          932,800                   

7.   SOLE DISPOSITIVE POWER

           0

8.   SHARED DISPOSITIVE POWER

          932,800                    

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          See 6 and 8 above.

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
     EXCLUDES CERTAIN SHARES*    [   ]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

          3.4%                               

12.  TYPE OF REPORTING PERSON*

          IA





1.   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

        Nicholas M. Maounis

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

        (a) [x] 
        (b) [ ]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

        United States

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

        0

6.   SHARED VOTING POWER

        932,800                            

7.   SOLE DISPOSITIVE POWER

        0

8.   SHARED DISPOSITIVE POWER

        932,800                            

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

        See 6 and 8 above.

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) 
     EXCLUDES CERTAIN SHARES*    [   ]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         3.4%                               

12.  TYPE OF REPORTING PERSON*

         IN, HC




This statement is filed with respect to the shares of common stock, having $.001
par value (the  "Common  Stock") of Inverness  Medical  Innovations,  Inc.  (the
"Issuer") beneficially owned by Amaranth LLC and Amaranth Global Equities Master
Fund Limited,  both Cayman Islands exempted companies,  Amaranth Advisors L.L.C.
and Nicholas M. Maounis ("Maounis")  (collectively,  the "Reporting Persons") as
of January 20, 2006 and amends and  supplements  the Schedule 13G filed December
23, 2004 (the "Schedule 13G").  Except as set forth herein,  the Schedule 13G is
unmodified.


Item 4.   Ownership.

     Provide  the  following  information  regarding  the  aggregate  number and
percentage of the class of securities of the issuer identified in Item 1.

(a) Amount beneficially owned:

           932,800


(b) Percent of class:

           3.4%              


(c) Number of shares as to which such person has:

      (i) Sole power to vote or direct the vote

            0

      (ii) Shared power to vote or to direct the vote

            See Item 4(a).

      (iii) Sole power to dispose or to direct the disposition of

             0

      (iv) Shared power to dispose or to direct the disposition of

             See Item 4(a).


Item 5.   Ownership of Five Percent or Less of a Class.

If this  statement  is being filed to report the fact that as of the date hereof
the Reporting  Persons have ceased to be the beneficial  owner of more than five
percent of the class of securities, check the following [X].



Item 7.   Identification and Classification of the Subsidiary Which Acquired 
          the Security Being Reported on by the Parent Holding Company.

          Not applicable


Item 10. Certification.

By signing below the  undersigned  certifies  that, to the best of its knowledge
and belief, the securities  referred to above were not acquired and are not held
for the purpose of or with the effect of changing or influencing  the control of
the  issuer  of the  securities  and  were  not  acquired  and are  not  held in
connection  with or as a participant in any  transaction  having that purpose or
effect.






                                   SIGNATURES

     After reasonable inquiry and to the best of its knowledge and belief,  each
of the undersigned  certifies that the information  with respect to it set forth
in this statement is true, complete, and correct.


Dated:   January 20, 2006           

          AMARANTH LLC,
                   by Amaranth Advisors L.L.C., as Trading Advisor

                   By: /s/ Nicholas M. Maounis                         
                       ------------------------------------------------
                        Nicholas M. Maounis,
                        Managing Member

          AMARANTH GLOBAL EQUITIES MASTER FUND LIMITED,
                   by Amaranth Advisors L.L.C., as Trading Advisor

                   By: /s/ Nicholas M. Maounis                         
                       ------------------------------------------------
                        Nicholas M. Maounis,
                        Managing Member

          AMARANTH ADVISORS L.L.C.,

                   By:  /s/ Nicholas M. Maounis                        
                       ------------------------------------------------
                        Nicholas M. Maounis,
                        Managing Member

          NICHOLAS M. MAOUNIS

                                                                       
                        /s/ Nicholas M. Maounis                        
                       ------------------------------------------------
                        Nicholas M. Maounis